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- AM-6545 abstract "AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor, and was developed for the treatment of obesity. Other cannabinoid antagonists such as rimonabant have been marketed for this application, but have subsequently been withdrawn from sale because of centrally mediated side effects such as depression and nausea. Because AM-6545 does not cross the blood–brain barrier to any significant extent, it does not produce these kinds of side effects, but has still been shown to effectively reduce appetite and food consumption in animal studies.".
- AM-6545 casNumber "1245626-05-4".
- AM-6545 iupacName "5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide".
- AM-6545 pubchem "46912919".
- AM-6545 thumbnail AM-6545_structure.png?width=300.
- AM-6545 wikiPageID "34540626".
- AM-6545 wikiPageRevisionID "605160648".
- AM-6545 c "26".
- AM-6545 casNumber "1245626".
- AM-6545 chemspiderid "26333263".
- AM-6545 cl "2".
- AM-6545 drugbankRef "=".
- AM-6545 h "23".
- AM-6545 hasPhotoCollection AM-6545.
- AM-6545 inchi "1".
- AM-6545 inchikey "XBHQLFVDGLPBCK-UHFFFAOYAZ".
- AM-6545 iupacName "5".
- AM-6545 molecularWeight "556.463".
- AM-6545 n "5".
- AM-6545 o "3".
- AM-6545 pubchem "46912919".
- AM-6545 s "1".
- AM-6545 smiles "O=S4CCNNCc1nnc-c3ccccc3".
- AM-6545 stdinchi "1".
- AM-6545 stdinchikey "XBHQLFVDGLPBCK-UHFFFAOYSA-N".
- AM-6545 verifiedfields "changed".
- AM-6545 width "280".
- AM-6545 subject Category:AM_cannabinoids.
- AM-6545 subject Category:CB1_receptor_antagonists.
- AM-6545 subject Category:Cannabinoids.
- AM-6545 type Drug.
- AM-6545 type FunctionalSubstance.
- AM-6545 comment "AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor, and was developed for the treatment of obesity. Other cannabinoid antagonists such as rimonabant have been marketed for this application, but have subsequently been withdrawn from sale because of centrally mediated side effects such as depression and nausea.".
- AM-6545 label "AM-6545".
- AM-6545 sameAs m.0j244km.
- AM-6545 sameAs Q4652496.
- AM-6545 sameAs Q4652496.
- AM-6545 wasDerivedFrom AM-6545?oldid=605160648.
- AM-6545 depiction AM-6545_structure.png.
- AM-6545 isPrimaryTopicOf AM-6545.
