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- AM251 abstract "AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists. In AM-251 the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group. The resulting compound exhibits slightly better binding affinity for the CB1 receptor (with a Ki value of 7.5nM) than SR141716A, which has a Ki value of 11.5nM, AM-251 is, however, about two-fold more selective for the CB1 receptor when compared to SR141716A.".
- AM251 casNumber "183232-66-8".
- AM251 iupacName "1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-".
- AM251 iupacName "N-(1-piperidyl)pyrazole-3-carboxamide".
- AM251 pubchem "2125".
- AM251 thumbnail AM2512d.png?width=300.
- AM251 wikiPageID "3209411".
- AM251 wikiPageRevisionID "544204589".
- AM251 c "22".
- AM251 casNumber "183232".
- AM251 chembl "285932".
- AM251 chemspiderid "2040".
- AM251 cl "2".
- AM251 h "21".
- AM251 hasPhotoCollection AM251.
- AM251 i "1".
- AM251 image "AM2513d.png".
- AM251 iupacName "1".
- AM251 iupacName "N-pyrazole-3-carboxamide".
- AM251 iupharLigand "744".
- AM251 molecularWeight "555.238".
- AM251 n "4".
- AM251 o "1".
- AM251 pubchem "2125".
- AM251 smiles "O=Cc4nncc4C".
- AM251 stdinchi "1".
- AM251 stdinchikey "BUZAJRPLUGXRAB-UHFFFAOYSA-N".
- AM251 verifiedrevid "407629142".
- AM251 width "160".
- AM251 subject Category:AM_cannabinoids.
- AM251 subject Category:Amides.
- AM251 subject Category:CB1_receptor_antagonists.
- AM251 subject Category:Organochlorides.
- AM251 subject Category:Organoiodides.
- AM251 subject Category:Piperidines.
- AM251 subject Category:Pyrazoles.
- AM251 type Drug.
- AM251 type DrugProduct.
- AM251 type FunctionalSubstance.
- AM251 comment "AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists. In AM-251 the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group.".
- AM251 label "AM251".
- AM251 label "AM251".
- AM251 sameAs AM251.
- AM251 sameAs m.08zgbs.
- AM251 sameAs Q4652514.
- AM251 sameAs Q4652514.
- AM251 wasDerivedFrom AM251?oldid=544204589.
- AM251 depiction AM2512d.png.
- AM251 isPrimaryTopicOf AM251.
