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- ANTH_domain abstract "The ANTH domain is a membrane binding domain that shows weak specificity for PtdIns(4,5)P2. It was found in AP180 (a.k.a. CALM) endocytotic accessory protein that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.Its structure is a solenoid of 9 helices. The PtdIns(4,5)P2 binding residues are spread over several helices at the tip of the structure. The PtdIns(4,5)P2 binding sequence is Kx9Kx(K/R)(H/Y).An ANTH domain is also found in HIP1 and HIP1R, and the PtdIns(4,5)P2 binding sequence is conserved. More information is found on endocytosis.org.".
- ANTH_domain symbol "ANTH".
- ANTH_domain thumbnail 1hfa_opm.gif?width=300.
- ANTH_domain wikiPageExternalLink AP180.html.
- ANTH_domain wikiPageExternalLink pmidlookup?view=long&pmid=11161218.
- ANTH_domain wikiPageID "6910971".
- ANTH_domain wikiPageRevisionID "590594098".
- ANTH_domain caption "Clathrin assembly lymphoid myeloid leukemia protein".
- ANTH_domain hasPhotoCollection ANTH_domain.
- ANTH_domain interpro "IPR011417".
- ANTH_domain name "ANTH domain".
- ANTH_domain opmFamily "39".
- ANTH_domain opmProtein "1".
- ANTH_domain pdb "A:21-299 A:19-285 A:19-285 A:19-285 A:19-285".
- ANTH_domain pfam "PF07651".
- ANTH_domain symbol "ANTH".
- ANTH_domain subject Category:Peripheral_membrane_proteins.
- ANTH_domain subject Category:Protein_domains.
- ANTH_domain type Abstraction100002137.
- ANTH_domain type Attribute100024264.
- ANTH_domain type Chemical114806838.
- ANTH_domain type Compound114818238.
- ANTH_domain type Environment113934596.
- ANTH_domain type Macromolecule114944888.
- ANTH_domain type Material114580897.
- ANTH_domain type Matter100020827.
- ANTH_domain type Molecule114682133.
- ANTH_domain type OrganicCompound114727670.
- ANTH_domain type Part113809207.
- ANTH_domain type PeripheralMembraneProteins.
- ANTH_domain type PhysicalEntity100001930.
- ANTH_domain type Protein114728724.
- ANTH_domain type ProteinDomains.
- ANTH_domain type Relation100031921.
- ANTH_domain type Situation113927383.
- ANTH_domain type Sphere114514039.
- ANTH_domain type State100024720.
- ANTH_domain type Substance100019613.
- ANTH_domain type Thing100002452.
- ANTH_domain type Unit109465459.
- ANTH_domain type Biomolecule.
- ANTH_domain type Protein.
- ANTH_domain type BiologicalObject.
- ANTH_domain comment "The ANTH domain is a membrane binding domain that shows weak specificity for PtdIns(4,5)P2. It was found in AP180 (a.k.a. CALM) endocytotic accessory protein that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.Its structure is a solenoid of 9 helices. The PtdIns(4,5)P2 binding residues are spread over several helices at the tip of the structure.".
- ANTH_domain label "ANTH domain".
- ANTH_domain sameAs m.0gwmls.
- ANTH_domain sameAs Q4653058.
- ANTH_domain sameAs Q4653058.
- ANTH_domain sameAs ANTH_domain.
- ANTH_domain wasDerivedFrom ANTH_domain?oldid=590594098.
- ANTH_domain depiction 1hfa_opm.gif.
- ANTH_domain isPrimaryTopicOf ANTH_domain.
