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- AP2_adaptor_complex abstract "The AP2 adaptor complex is a multimeric protein that works on the plasma membrane to internalize cargo in clathrin-mediated endocytosis. It is a stable complex of four adaptins which give rise to a structure that has a core domain and two appendage domains attached to the core domain by polypeptide linkers. These appendage domains are sometimes called ears. The core domain binds to the membrane and to cargo destined for internalisation. The alpha and beta appendage domains bind to accessory proteins and to clathrin. Their interactions allow the temporal and spatial regulation of the assembly of clathrin-coated vesicles and their endocytosis.The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha and beta), a medium adaptin (mu), and a small adaptin (sigma): complex 2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1↑".
- AP2_adaptor_complex wikiPageExternalLink Adaptors.
- AP2_adaptor_complex wikiPageID "7075683".
- AP2_adaptor_complex wikiPageRevisionID "595156792".
- AP2_adaptor_complex hasPhotoCollection AP2_adaptor_complex.
- AP2_adaptor_complex subject Category:Membrane_biology.
- AP2_adaptor_complex subject Category:Peripheral_membrane_proteins.
- AP2_adaptor_complex comment "The AP2 adaptor complex is a multimeric protein that works on the plasma membrane to internalize cargo in clathrin-mediated endocytosis. It is a stable complex of four adaptins which give rise to a structure that has a core domain and two appendage domains attached to the core domain by polypeptide linkers. These appendage domains are sometimes called ears. The core domain binds to the membrane and to cargo destined for internalisation.".
- AP2_adaptor_complex label "AP2 adaptor complex".
- AP2_adaptor_complex sameAs m.0h2_ym.
- AP2_adaptor_complex sameAs Q4653198.
- AP2_adaptor_complex sameAs Q4653198.
- AP2_adaptor_complex wasDerivedFrom AP2_adaptor_complex?oldid=595156792.
- AP2_adaptor_complex isPrimaryTopicOf AP2_adaptor_complex.