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- APEX1 abstract "DNA-(apurinic or apyrimidinic site) lyase is an enzyme that in humans is encoded by the APEX1 gene.Apurinic/apyrimidinic (AP) sites (also called "abasic sites") occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication. All cells, from simple prokaryotes to humans, have evolved systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site, thereby initiating a process known as base excision repair (BER). The APEX gene (alternatively named APE1, HAP1, APEN) encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.".
- APEX1 entrezgene "328".
- APEX1 wikiPageID "14116765".
- APEX1 wikiPageRevisionID "603295060".
- APEX1 hasPhotoCollection APEX1.
- APEX1 requireManualInspection "no".
- APEX1 summaryText "Apurinic/apyrimidinic sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication. All cells, from simple prokaryotes to humans, have evolved systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site, thereby initiating a process known as base excision repair . The APEX gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.".
- APEX1 updateCitations "yes".
- APEX1 updatePage "yes".
- APEX1 updateProteinBox "yes".
- APEX1 updateSummary "yes".
- APEX1 type Biomolecule.
- APEX1 type Protein.
- APEX1 type BiologicalObject.
- APEX1 comment "DNA-(apurinic or apyrimidinic site) lyase is an enzyme that in humans is encoded by the APEX1 gene.Apurinic/apyrimidinic (AP) sites (also called "abasic sites") occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication. All cells, from simple prokaryotes to humans, have evolved systems to identify and repair such sites.".
- APEX1 label "APEX1".
- APEX1 sameAs m.03cv3xh.
- APEX1 sameAs Q4653286.
- APEX1 sameAs Q4653286.
- APEX1 sameAs 4180.
- APEX1 wasDerivedFrom APEX1?oldid=603295060.
- APEX1 isPrimaryTopicOf APEX1.