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- AT-hook abstract "The AT-hook is a DNA-binding motif present in many proteins, including the high mobility group (HMG) proteins, DNA-binding proteins from plants and hBRG1 protein, a central ATPase of the human switching/sucrose non-fermenting (SWI/SNF) remodeling complex.This motif consists of a conserved, palindromic, core sequence of proline-arginine-glycine-arginine-proline, although some AT-hooks contain only a single proline in the core sequence. AT-hooks also include a variable number of positively charged lysine and arginine residues on either side of the core sequence. The AT-hook binds to the minor groove of adenine-thymine (AT) rich DNA, hence the AT in the name. The rest of the name derives from a predicted asparagine/aspartate "hook" in the earliest AT-hooks reported in 1990. In 1997 structural studies using NMR determined that a DNA-bound AT-hook adopted a crescent or hook shape around the minor groove of a target DNA strand (pictured at right). HMGA proteins contain three AT-hooks, although some proteins contain as many as 30. The optimal binding sequences for AT-hook proteins are repeats of the form (ATAA)n or (TATT)n, although the optimal binding sequences for the core sequence of the AT-hook are AAAT and AATT.".
- AT-hook symbol "AT_hook".
- AT-hook thumbnail PDB_2eze_EBI.jpg?width=300.
- AT-hook wikiPageID "21801799".
- AT-hook wikiPageRevisionID "590661011".
- AT-hook caption "solution structure of a complex of the second dna binding domain of human hmg-i bound to dna dodecamer containing the prdii site of the interferon-beta promoter, nmr, 35 structures".
- AT-hook hasPhotoCollection AT-hook.
- AT-hook interpro "IPR017956".
- AT-hook name "AT_hook".
- AT-hook pfam "PF02178".
- AT-hook scop "2".
- AT-hook smart "AT_hook".
- AT-hook symbol "AT_hook".
- AT-hook subject Category:Molecular_genetics.
- AT-hook type Biomolecule.
- AT-hook type Protein.
- AT-hook type BiologicalObject.
- AT-hook comment "The AT-hook is a DNA-binding motif present in many proteins, including the high mobility group (HMG) proteins, DNA-binding proteins from plants and hBRG1 protein, a central ATPase of the human switching/sucrose non-fermenting (SWI/SNF) remodeling complex.This motif consists of a conserved, palindromic, core sequence of proline-arginine-glycine-arginine-proline, although some AT-hooks contain only a single proline in the core sequence.".
- AT-hook label "AT-hook".
- AT-hook sameAs m.05mzvv7.
- AT-hook sameAs Q4654569.
- AT-hook sameAs Q4654569.
- AT-hook wasDerivedFrom AT-hook?oldid=590661011.
- AT-hook depiction PDB_2eze_EBI.jpg.
- AT-hook isPrimaryTopicOf AT-hook.
