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- ATP2B1 abstract "Plasma membrane calcium-transporting ATPase 1 is an enzyme that in humans is encoded by the ATP2B1 gene.The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.".
- ATP2B1 entrezgene "490".
- ATP2B1 wikiPageID "14757972".
- ATP2B1 wikiPageRevisionID "590713840".
- ATP2B1 hasPhotoCollection ATP2B1.
- ATP2B1 requireManualInspection "no".
- ATP2B1 summaryText "The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.".
- ATP2B1 updateCitations "yes".
- ATP2B1 updatePage "yes".
- ATP2B1 updateProteinBox "yes".
- ATP2B1 updateSummary "yes".
- ATP2B1 type Biomolecule.
- ATP2B1 type Protein.
- ATP2B1 type BiologicalObject.
- ATP2B1 comment "Plasma membrane calcium-transporting ATPase 1 is an enzyme that in humans is encoded by the ATP2B1 gene.The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis.".
- ATP2B1 label "ATP2B1".
- ATP2B1 sameAs m.03gwy65.
- ATP2B1 sameAs Q4654809.
- ATP2B1 sameAs Q4654809.
- ATP2B1 wasDerivedFrom ATP2B1?oldid=590713840.
- ATP2B1 isPrimaryTopicOf ATP2B1.