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- ATP6V1B2 abstract "V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.In melanocytic cells ATP6V1B2 gene expression may be regulated by MITF.".
- ATP6V1B2 entrezgene "526".
- ATP6V1B2 wikiPageID "14795371".
- ATP6V1B2 wikiPageRevisionID "590714449".
- ATP6V1B2 hasPhotoCollection ATP6V1B2.
- ATP6V1B2 requireManualInspection "no".
- ATP6V1B2 summaryText "This gene encodes a component of vacuolar ATPase , a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. In melanocytic cells ATP6V1B2 gene expression may be regulated by MITF.".
- ATP6V1B2 updateCitations "yes".
- ATP6V1B2 updatePage "yes".
- ATP6V1B2 updateProteinBox "yes".
- ATP6V1B2 updateSummary "yes".
- ATP6V1B2 type Biomolecule.
- ATP6V1B2 type Protein.
- ATP6V1B2 type BiologicalObject.
- ATP6V1B2 comment "V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.".
- ATP6V1B2 label "ATP6V1B2".
- ATP6V1B2 sameAs m.03gy5rp.
- ATP6V1B2 sameAs Q4654845.
- ATP6V1B2 sameAs Q4654845.
- ATP6V1B2 wasDerivedFrom ATP6V1B2?oldid=590714449.
- ATP6V1B2 isPrimaryTopicOf ATP6V1B2.