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- ATPIF1 abstract "ATPase inhibitor, mitochondrial is an enzyme that in humans is encoded by the ATPIF1 gene.This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified.It prevents ATPase from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation ATP synthase inhibitor forms a one to one complex with the F1 ATPase, possibly by binding at the alpha-beta interface. It is thought to inhibit ATP synthesis by preventing the release of ATP. The inhibitor has two oligomeric states, dimer (the active state) and tetramer. At low pH, the inhibitor forms a dimer via antiparallel coiled coil interactions between the C-terminal regions of two monomers. At high pH, the inhibitor forms tetramers and higher oligomers by coiled coil interactions involving the N terminus and inhibitory region, thus preventing the inhibitory activity.".
- ATPIF1 entrezgene "93974".
- ATPIF1 symbol "IATP".
- ATPIF1 thumbnail PDB_1hf9_EBI.jpg?width=300.
- ATPIF1 wikiPageID "15227316".
- ATPIF1 wikiPageRevisionID "590714760".
- ATPIF1 caption "c-terminal coiled-coil domain from bovine if1".
- ATPIF1 hasPhotoCollection ATPIF1.
- ATPIF1 interpro "IPR007648".
- ATPIF1 name "Mitochondrial ATPase inhibitor, IATP".
- ATPIF1 pfam "PF04568".
- ATPIF1 requireManualInspection "no".
- ATPIF1 scop "1".
- ATPIF1 summaryText "This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified.".
- ATPIF1 symbol "IATP".
- ATPIF1 updateCitations "yes".
- ATPIF1 updatePage "yes".
- ATPIF1 updateProteinBox "yes".
- ATPIF1 updateSummary "yes".
- ATPIF1 subject Category:Genes_mutated_in_mice.
- ATPIF1 subject Category:Protein_families.
- ATPIF1 type Biomolecule.
- ATPIF1 type Protein.
- ATPIF1 type BiologicalObject.
- ATPIF1 comment "ATPase inhibitor, mitochondrial is an enzyme that in humans is encoded by the ATPIF1 gene.This gene encodes a mitochondrial ATPase inhibitor.".
- ATPIF1 label "ATPIF1".
- ATPIF1 sameAs m.03hmkr_.
- ATPIF1 sameAs Q4654867.
- ATPIF1 sameAs Q4654867.
- ATPIF1 wasDerivedFrom ATPIF1?oldid=590714760.
- ATPIF1 depiction PDB_1hf9_EBI.jpg.
- ATPIF1 isPrimaryTopicOf ATPIF1.
