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- ATP_cone abstract "In molecular biology, the ATP-cone is an evolutionarily mobile, ATP-binding regulatory domain which is found in a variety of proteins including ribonucleotide reductases, phosphoglycerate kinases and transcriptional regulators.In ribonucleotide reductase protein R1 from Escherichia coli this domain is located at the N terminus, and is composed mostly of helices. It forms part of the allosteric effector region and contains the general allosteric activity site in a cleft located at the tip of the N-terminal region. This site binds either ATP (activating) or dATP (inhibitory), with the base bound in a hydrophobic pocket and the phosphates bound to basic residues. Substrate binding to this site is thought to affect enzyme activity by altering the relative positions of the two subunits of ribonucleotide reductase.".
- ATP_cone symbol "ATP-cone".
- ATP_cone thumbnail PDB_7r1r_EBI.jpg?width=300.
- ATP_cone wikiPageID "32149638".
- ATP_cone wikiPageRevisionID "591085709".
- ATP_cone caption "ribonucleotide reductase e441q mutant r1 protein from escherichia coli".
- ATP_cone hasPhotoCollection ATP_cone.
- ATP_cone interpro "IPR005144".
- ATP_cone name "ATP-cone".
- ATP_cone pfam "PF03477".
- ATP_cone scop "7".
- ATP_cone symbol "ATP-cone".
- ATP_cone subject Category:Protein_domains.
- ATP_cone type Abstraction100002137.
- ATP_cone type Attribute100024264.
- ATP_cone type Environment113934596.
- ATP_cone type ProteinDomains.
- ATP_cone type Situation113927383.
- ATP_cone type Sphere114514039.
- ATP_cone type State100024720.
- ATP_cone type Biomolecule.
- ATP_cone type Protein.
- ATP_cone type BiologicalObject.
- ATP_cone comment "In molecular biology, the ATP-cone is an evolutionarily mobile, ATP-binding regulatory domain which is found in a variety of proteins including ribonucleotide reductases, phosphoglycerate kinases and transcriptional regulators.In ribonucleotide reductase protein R1 from Escherichia coli this domain is located at the N terminus, and is composed mostly of helices.".
- ATP_cone label "ATP cone".
- ATP_cone sameAs m.0gx23j5.
- ATP_cone sameAs Q4654876.
- ATP_cone sameAs Q4654876.
- ATP_cone sameAs ATP_cone.
- ATP_cone wasDerivedFrom ATP_cone?oldid=591085709.
- ATP_cone depiction PDB_7r1r_EBI.jpg.
- ATP_cone isPrimaryTopicOf ATP_cone.
