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• ATP_phosphoribosyltransferase abstract "In enzymology, an ATP phosphoribosyltransferase (EC 2.4.2.17) is an enzyme that catalyzes the chemical reaction1-(5-phospho-D-ribosyl)-ATP + diphosphate ATP + 5-phospho-alpha-D-ribose 1-diphosphateThus, the two substrates of this enzyme are 1-(5-phospho-D-ribosyl)-ATP and diphosphate, whereas its two products are ATP and 5-phospho-alpha-D-ribose 1-diphosphate.This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase. Other names in common use include phosphoribosyl-ATP pyrophosphorylase, adenosine triphosphate phosphoribosyltransferase, phosphoribosyladenosine triphosphate:pyrophosphate, phosphoribosyltransferase, phosphoribosyl ATP synthetase, phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase, phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase, phosphoribosyladenosine triphosphate pyrophosphorylase, and phosphoribosyladenosine triphosphate synthetase. This enzyme catalyses the first step in the biosynthesis of histidine in bacteria, fungi and plants. It is a member of the larger phosphoribosyltransferase superfamily of enzymes which catalyse the condensation of 5-phospho-alpha-D-ribose 1-diphosphate with nitrogenous bases in the presence of divalent metal ions.Histidine biosynthesis is an energetically expensive process and ATP phosphoribosyltransferase activity is subject to control at several levels. Transcriptional regulation is based primarily on nutrient conditions and determines the amount of enzyme present in the cell, while feedback inihibition rapidly modulates activity in response to cellular conditions. The enzyme has been shown to be inhibited by 1-(5-phospho-D-ribosyl)-ATP, histidine, ppGpp (a signal associated with adverse environmental conditions) and ADP and AMP (which reflect the overall energy status of the cell). As this pathway of histidine biosynthesis is present only in prokaryotes, plants and fungi, this enzyme is a promising target for the development of novel antimicrobial compounds and herbicides.ATP phosphoribosyltransferase is found in two distinct forms: a long form containing two catalytic domains and a C-terminal regulatory domain, and a short form in which the regulatory domain is missing. The long form is catalytically competent, but in organisms with the short form, a histidyl-tRNA synthetase paralogue, HisZ, is required for enzyme activity.The structures of the long form enzymes from Escherichia coli and Mycobacterium tuberculosis have been determined. The enzyme itself exists in equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the binding of the natural substrates and inhibitors of the enzyme. The two catalytic domains are linked by a two-stranded beta-sheet and together form a "periplasmic binding protein fold". A crevice between these domains contains the active site. The C-terminal domain is not directly involved in catalysis but appears to be involved the formation of hexamers, induced by the binding of inhibitors such as histidine to the enzyme, thus regulating activity.".
• ATP_phosphoribosyltransferase ecNumber "2.4.2.17".
• ATP_phosphoribosyltransferase thumbnail PDB_1h3d_EBI.jpg?width=300.
• ATP_phosphoribosyltransferase wikiPageID "14650659".
• ATP_phosphoribosyltransferase wikiPageRevisionID "590713452".
• ATP_phosphoribosyltransferase caption "atp phosphoribosyltransferase from mycobacterium tuberculosis in complex with amp and histidine".
• ATP_phosphoribosyltransferase caption "structure of the e.coli atp-phosphoribosyltransferase".
• ATP_phosphoribosyltransferase casNumber "9031".
• ATP_phosphoribosyltransferase ecNumber "2.4".
• ATP_phosphoribosyltransferase goCode "3879".
• ATP_phosphoribosyltransferase hasPhotoCollection ATP_phosphoribosyltransferase.
• ATP_phosphoribosyltransferase interpro "IPR013115".
• ATP_phosphoribosyltransferase interpro "IPR013820".
• ATP_phosphoribosyltransferase iubmbEcNumber "2".
• ATP_phosphoribosyltransferase name "ATP phosphoribosyltransferase".
• ATP_phosphoribosyltransferase name "HisG, C-terminal domain".
• ATP_phosphoribosyltransferase pfam "PF01634".
• ATP_phosphoribosyltransferase pfam "PF08029".
• ATP_phosphoribosyltransferase pfamClan "CL0089".
• ATP_phosphoribosyltransferase pfamClan "CL0177".
• ATP_phosphoribosyltransferase prosite "PDOC01020".
• ATP_phosphoribosyltransferase scop "1".
• ATP_phosphoribosyltransferase symbol "HisG".
• ATP_phosphoribosyltransferase symbol "HisG_C".
• ATP_phosphoribosyltransferase subject Category:EC_2.4.2.
• ATP_phosphoribosyltransferase subject Category:Enzymes_of_known_structure.
• ATP_phosphoribosyltransferase type Abstraction100002137.
• ATP_phosphoribosyltransferase type Activator114723079.
• ATP_phosphoribosyltransferase type Catalyst114723628.
• ATP_phosphoribosyltransferase type Chemical114806838.
• ATP_phosphoribosyltransferase type Compound114818238.
• ATP_phosphoribosyltransferase type Enzyme114732946.
• ATP_phosphoribosyltransferase type EnzymesOfKnownStructure.
• ATP_phosphoribosyltransferase type Macromolecule114944888.
• ATP_phosphoribosyltransferase type Material114580897.
• ATP_phosphoribosyltransferase type Matter100020827.
• ATP_phosphoribosyltransferase type Molecule114682133.
• ATP_phosphoribosyltransferase type OrganicCompound114727670.
• ATP_phosphoribosyltransferase type Part113809207.
• ATP_phosphoribosyltransferase type PhysicalEntity100001930.
• ATP_phosphoribosyltransferase type Protein114728724.
• ATP_phosphoribosyltransferase type Relation100031921.
• ATP_phosphoribosyltransferase type Substance100019613.
• ATP_phosphoribosyltransferase type Thing100002452.
• ATP_phosphoribosyltransferase type Unit109465459.
• ATP_phosphoribosyltransferase type Biomolecule.
• ATP_phosphoribosyltransferase type Enzyme.
• ATP_phosphoribosyltransferase type BiologicalObject.
• ATP_phosphoribosyltransferase comment "In enzymology, an ATP phosphoribosyltransferase (EC 2.4.2.17) is an enzyme that catalyzes the chemical reaction1-(5-phospho-D-ribosyl)-ATP + diphosphate ATP + 5-phospho-alpha-D-ribose 1-diphosphateThus, the two substrates of this enzyme are 1-(5-phospho-D-ribosyl)-ATP and diphosphate, whereas its two products are ATP and 5-phospho-alpha-D-ribose 1-diphosphate.This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases.".
• ATP_phosphoribosyltransferase label "ATP phosphoribosyltransferase".
• ATP_phosphoribosyltransferase sameAs m.03grwhg.
• ATP_phosphoribosyltransferase sameAs Q4654880.
• ATP_phosphoribosyltransferase sameAs Q4654880.
• ATP_phosphoribosyltransferase sameAs 2263.
• ATP_phosphoribosyltransferase sameAs ATP_phosphoribosyltransferase.
• ATP_phosphoribosyltransferase wasDerivedFrom ATP_phosphoribosyltransferase?oldid=590713452.
• ATP_phosphoribosyltransferase depiction PDB_1h3d_EBI.jpg.
• ATP_phosphoribosyltransferase isPrimaryTopicOf ATP_phosphoribosyltransferase.
• ATP_phosphoribosyltransferase name "ATP phosphoribosyltransferase".