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- Actinin_alpha_4 abstract "Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.".
- Actinin_alpha_4 entrezgene "81".
- Actinin_alpha_4 wikiPageID "14725938".
- Actinin_alpha_4 wikiPageRevisionID "602988054".
- Actinin_alpha_4 hasPhotoCollection Actinin_alpha_4.
- Actinin_alpha_4 requireManualInspection "no".
- Actinin_alpha_4 summaryText "Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.".
- Actinin_alpha_4 updateCitations "yes".
- Actinin_alpha_4 updatePage "yes".
- Actinin_alpha_4 updateProteinBox "yes".
- Actinin_alpha_4 updateSummary "yes".
- Actinin_alpha_4 type Biomolecule.
- Actinin_alpha_4 type Protein.
- Actinin_alpha_4 type BiologicalObject.
- Actinin_alpha_4 comment "Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane.".
- Actinin_alpha_4 label "Actinin alpha 4".
- Actinin_alpha_4 sameAs m.03gvpky.
- Actinin_alpha_4 sameAs Q4676903.
- Actinin_alpha_4 sameAs Q4676903.
- Actinin_alpha_4 sameAs ACTN4.
- Actinin_alpha_4 wasDerivedFrom Actinin_alpha_4?oldid=602988054.
- Actinin_alpha_4 isPrimaryTopicOf Actinin_alpha_4.