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- Acyl_carrier_protein abstract "The acyl carrier protein (ACP) is an important component in both fatty acid and polyketide biosynthesis with the growing chain bound during synthesis as a thiol ester at the distal thiol of a 4'-phosphopantetheine moiety. The protein is expressed in the inactive apo form and the 4'-phosphopantetheine moiety must be post-translationally attached to a conserved serine residue on the ACP by the action of holo-acyl carrier protein synthase (ACPS), a phosphopantetheinyl transferase.4'-Phosphopantetheine is an essential prosthetic group of several acyl carrier proteins involved in pathways of primary and secondary metabolism including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). Phosphopantetheine fulfills two demands in these biosynthetic pathways. First, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich linkage. Second, the flexibility and length of the phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to have access to spatially distinct enzyme-active sites. This increases the effective molarity of the intermediate and allows an assembly line-like process.The ACPs are small negatively charged α-helical bundle proteins with a high degree of structural and amino acid similarity. The structures of a number of acyl carrier proteins have been solved using various NMR and crystallography techniques.The ACPs are related in structure and mechanism to the peptidyl carrier proteins (PCP) from nonribosomal peptide synthases.".
- Acyl_carrier_protein thumbnail Act_acp.png?width=300.
- Acyl_carrier_protein wikiPageID "2469066".
- Acyl_carrier_protein wikiPageRevisionID "541698167".
- Acyl_carrier_protein hasPhotoCollection Acyl_carrier_protein.
- Acyl_carrier_protein subject Category:Proteins.
- Acyl_carrier_protein type Abstraction100002137.
- Acyl_carrier_protein type Chemical114806838.
- Acyl_carrier_protein type Compound114818238.
- Acyl_carrier_protein type Macromolecule114944888.
- Acyl_carrier_protein type Material114580897.
- Acyl_carrier_protein type Matter100020827.
- Acyl_carrier_protein type Molecule114682133.
- Acyl_carrier_protein type OrganicCompound114727670.
- Acyl_carrier_protein type Part113809207.
- Acyl_carrier_protein type PhysicalEntity100001930.
- Acyl_carrier_protein type Protein114728724.
- Acyl_carrier_protein type Proteins.
- Acyl_carrier_protein type Relation100031921.
- Acyl_carrier_protein type Substance100019613.
- Acyl_carrier_protein type Thing100002452.
- Acyl_carrier_protein type Unit109465459.
- Acyl_carrier_protein comment "The acyl carrier protein (ACP) is an important component in both fatty acid and polyketide biosynthesis with the growing chain bound during synthesis as a thiol ester at the distal thiol of a 4'-phosphopantetheine moiety.".
- Acyl_carrier_protein label "ACP (białko)".
- Acyl_carrier_protein label "Acyl carrier protein".
- Acyl_carrier_protein label "Protéine porteuse d'acyle".
- Acyl_carrier_protein label "酰基载体蛋白".
- Acyl_carrier_protein sameAs Protéine_porteuse_d'acyle.
- Acyl_carrier_protein sameAs Acyl_carrier_protein.
- Acyl_carrier_protein sameAs ACP_(białko).
- Acyl_carrier_protein sameAs m.07g6y6.
- Acyl_carrier_protein sameAs Q1087229.
- Acyl_carrier_protein sameAs Q1087229.
- Acyl_carrier_protein sameAs Acyl_carrier_protein.
- Acyl_carrier_protein wasDerivedFrom Acyl_carrier_protein?oldid=541698167.
- Acyl_carrier_protein depiction Act_acp.png.
- Acyl_carrier_protein isPrimaryTopicOf Acyl_carrier_protein.
