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- Afobazole abstract "Afobazole is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions, making it more selective in action than many currently used drugs for this application. Its mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown afobazole to be well tolerated and reasonably effective for the treatment of anxiety, although it has not been introduced into widespread clinical use outside of Russia. The compound has not been evaluated by the FDA. It is unscheduled in the US and legal to import by private citizens for personal use.".
- Afobazole atcPrefix "none".
- Afobazole casNumber "173352-39-1".
- Afobazole fdaUniiCode "HDO6HX6NZU".
- Afobazole iupacName "5-ethoxy-2-[2-(morpholino)-ethylthio]benzimidazole".
- Afobazole pubchem "9862937".
- Afobazole thumbnail Afobazole.svg?width=300.
- Afobazole wikiPageID "25162841".
- Afobazole wikiPageRevisionID "583043701".
- Afobazole atcPrefix "none".
- Afobazole c "15".
- Afobazole casNumber "173352".
- Afobazole chemspiderid "8038633".
- Afobazole eliminationHalfLife "1440.0".
- Afobazole h "21".
- Afobazole hasPhotoCollection Afobazole.
- Afobazole inchi "1".
- Afobazole inchikey "WWNUCVSRRUDYPP-UHFFFAOYAO".
- Afobazole iupacName "5".
- Afobazole legalStatus "Legal".
- Afobazole molecularWeight "307.41".
- Afobazole n "3".
- Afobazole o "2".
- Afobazole pubchem "9862937".
- Afobazole routesOfAdministration "Oral".
- Afobazole s "1".
- Afobazole smiles "C3COCCN3CCScnc1ccc2OCC".
- Afobazole stdinchi "1".
- Afobazole stdinchikey "WWNUCVSRRUDYPP-UHFFFAOYSA-N".
- Afobazole unii "HDO6HX6NZU".
- Afobazole verifiedfields "changed".
- Afobazole verifiedrevid "477243457".
- Afobazole width "220".
- Afobazole subject Category:Anxiolytics.
- Afobazole subject Category:Benzimidazoles.
- Afobazole subject Category:Morpholines.
- Afobazole subject Category:Phenol_ethers.
- Afobazole subject Category:Thioethers.
- Afobazole type Abstraction100002137.
- Afobazole type Element114840755.
- Afobazole type Matter100020827.
- Afobazole type Part113809207.
- Afobazole type PhenolEthers.
- Afobazole type PhysicalEntity100001930.
- Afobazole type Quintessence114847103.
- Afobazole type Relation100031921.
- Afobazole type Substance100019613.
- Afobazole type Drug.
- Afobazole type DrugProduct.
- Afobazole type FunctionalSubstance.
- Afobazole comment "Afobazole is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions, making it more selective in action than many currently used drugs for this application. Its mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms.".
- Afobazole label "Afobazole".
- Afobazole label "Afobazole".
- Afobazole label "Афобазол".
- Afobazole sameAs Afobazole.
- Afobazole sameAs m.09gjt_3.
- Afobazole sameAs Q2090655.
- Afobazole sameAs Q2090655.
- Afobazole sameAs Afobazole.
- Afobazole wasDerivedFrom Afobazole?oldid=583043701.
- Afobazole depiction Afobazole.svg.
- Afobazole isPrimaryTopicOf Afobazole.