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- Ajoene abstract "Ajoene /ˈɑːhoʊ.iːn/ is a chemical compound available from garlic (Allium sativum). It was first isolated in 1983 by its inventors (patent US4665088 [1][2] ) Rafael Apitz-Castro and Mahendra K. Jain and further studied in the laboratory by Eric Block together with the inventors and other coworkers. The name (and pronunciation) is derived from "ajo", the Spanish word for garlic. It is found as a mixture of two isomers, E-, and Z- 4,5,9-trithiadodeca-1,6,11-triene 9-oxide.Ajoene, an unsaturated disulfide, is formed from a chemical reaction involving two allicin molecules. Allicin is a sulfinyl compound that gives garlic its strong odor and flavor. The release of allicin occurs after a garlic clove is crushed or finely chopped. Subsequent formation of ajoene occurs when allicin is dissolved in various solvents including edible oils. Ajoene is also found in garlic extract. Ajoene is most stable and most abundant in macerate of garlic (chopped garlic in edible oil).Scientists have found that ajoene has many properties of interest to current medicine. It functions as an antioxidant, by inhibiting the release of superoxide. Ajoene also has antithrombotic (anti-clotting) properties, which helps prevent platelets in the blood from forming blood clots, potentially reducing the risk of heart disease and stroke in humans. Ajoene has shown potential virucidal properties against a number of viruses including vesicular stomatitis, vaccinia, human rhinovirus parainfluenza, and herpes simplex. In the infected cell system of a human immunodeficiency virus (HIV), it is shown to block the integrin-dependent processes. Ajoene is also known to have effective broad-spectrum antimicrobial (antibacterial and antifungal) properties, helpful in preventing yeast infection (Candida albicans) and treating athlete's foot (tinea pedis), for example. Ajoene has been investigated as an anti-leukemia agent for acute myeloid leukemia therapy. Ajoene has been found to decrease basal-cell carcinoma tumor size by inducing apoptosis while it has also been shown effective in inhibiting tumor cell growth by targeting the microtubule cytoskeleton of such cells and by other mechanisms. In 2012 it was reported that ajoene inhibits genes controlled by quorum sensing.".
- Ajoene thumbnail Ajoene-skeletal.png?width=300.
- Ajoene wikiPageExternalLink detail.jsf?docId=US37642397&recNum=2&office=&queryString=ALLNUM%3A%284665088%29&prevFilter=&sortOption=Pub+Date+Desc&maxRec=2.
- Ajoene wikiPageExternalLink 4665088.
- Ajoene wikiPageID "1653761".
- Ajoene wikiPageRevisionID "603834535".
- Ajoene hasPhotoCollection Ajoene.
- Ajoene imagefile "Ajoene-skeletal.png".
- Ajoene verifiedrevid "453573796".
- Ajoene subject Category:Organic_disulfides.
- Ajoene type ChemicalCompound.
- Ajoene type ChemicalSubstance.
- Ajoene type ChemicalObject.
- Ajoene type Thing.
- Ajoene comment "Ajoene /ˈɑːhoʊ.iːn/ is a chemical compound available from garlic (Allium sativum). It was first isolated in 1983 by its inventors (patent US4665088 [1][2] ) Rafael Apitz-Castro and Mahendra K. Jain and further studied in the laboratory by Eric Block together with the inventors and other coworkers. The name (and pronunciation) is derived from "ajo", the Spanish word for garlic.".
- Ajoene label "Ajoen".
- Ajoene label "Ajoene".
- Ajoene label "Ajoene".
- Ajoene label "Ajoène".
- Ajoene label "アホエン".
- Ajoene sameAs Αχοένιο.
- Ajoene sameAs Ajoène.
- Ajoene sameAs Ajoene.
- Ajoene sameAs アホエン.
- Ajoene sameAs Ajoen.
- Ajoene sameAs m.05ky7t.
- Ajoene sameAs Q338762.
- Ajoene sameAs Q338762.
- Ajoene wasDerivedFrom Ajoene?oldid=603834535.
- Ajoene depiction Ajoene-skeletal.png.
- Ajoene isPrimaryTopicOf Ajoene.