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- Ajulemic_acid abstract "Ajulemic acid (AB-III-56, HU-239, IP-751, CPL 7075, CT-3, Resunab) is a synthetic cannabinoid derivative of the non-psychoactive THC metabolite 11-nor-9-carboxy-THC that shows useful analgesic and anti-inflammatory effects without causing a subjective "high". It is being developed for the treatment of neuropathic pain and inflammatory conditions such as arthritis. It does not however share the anti-emetic effects of other cannabinoids but may be useful for treating pain and chronic inflammatory conditions where nausea is not present. Side effects include dry mouth, tiredness and dizziness. The mechanism of action has not yet been fully established, but ajulemic acid may activate the CB2 receptor in the periphery leading to production of resolving eicosanoids. Studies in animals at doses up to 40 mg/kg show minimal psychoactivity of ajulemic acid, comparable to that produced by tetrahydrocannabinol,. Likewise, there was no difference between ajulemic acid and placebo on the "cannabimimetic" assay when used in humans at therapeutic doses. A new highly purified composition of ajulemic acid named Resunab is being developed by Corbus Pharmaceuticals (formerly JB Therapeutics)for the treatment of orphan life-threatening inflammatory diseases.".
- Ajulemic_acid atcPrefix "none".
- Ajulemic_acid casNumber "137945-48-3".
- Ajulemic_acid iupacName "(6aR,10aR)-3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-Dibenzo(b,d)pyran-9-carboxylic acid".
- Ajulemic_acid pubchem "3083542".
- Ajulemic_acid thumbnail Ajulemicacid.png?width=300.
- Ajulemic_acid wikiPageID "10905011".
- Ajulemic_acid wikiPageRevisionID "602850702".
- Ajulemic_acid atcPrefix "none".
- Ajulemic_acid c "25".
- Ajulemic_acid casNumber "137945".
- Ajulemic_acid chembl "456341".
- Ajulemic_acid chemspiderid "21106251".
- Ajulemic_acid h "36".
- Ajulemic_acid hasPhotoCollection Ajulemic_acid.
- Ajulemic_acid inchi "1".
- Ajulemic_acid inchikey "QHGPTMABBHVVQU-VOBHOPKGBO".
- Ajulemic_acid iupacName "-3".
- Ajulemic_acid legalStatus "patent pending".
- Ajulemic_acid metabolism "minimal".
- Ajulemic_acid molecularWeight "400.551".
- Ajulemic_acid o "4".
- Ajulemic_acid pubchem "3083542".
- Ajulemic_acid routesOfAdministration "oral".
- Ajulemic_acid smiles "CCc2cc1OC[C@@H]3/C=C\CC=O".
- Ajulemic_acid stdinchi "1".
- Ajulemic_acid stdinchikey "QHGPTMABBHVVQU-VOBHOPKGSA-N".
- Ajulemic_acid tradename "Resunab".
- Ajulemic_acid verifiedfields "changed".
- Ajulemic_acid verifiedrevid "477315042".
- Ajulemic_acid width "200".
- Ajulemic_acid subject Category:Benzochromenes.
- Ajulemic_acid subject Category:Cannabinoids.
- Ajulemic_acid subject Category:Carboxylic_acids.
- Ajulemic_acid subject Category:HU_cannabinoids.
- Ajulemic_acid subject Category:Phenols.
- Ajulemic_acid type Abstraction100002137.
- Ajulemic_acid type Acid114607521.
- Ajulemic_acid type CarboxylicAcid114739360.
- Ajulemic_acid type CarboxylicAcids.
- Ajulemic_acid type Chemical114806838.
- Ajulemic_acid type Compound114818238.
- Ajulemic_acid type Material114580897.
- Ajulemic_acid type Matter100020827.
- Ajulemic_acid type OrganicCompound114727670.
- Ajulemic_acid type Part113809207.
- Ajulemic_acid type Phenol114989545.
- Ajulemic_acid type Phenols.
- Ajulemic_acid type PhysicalEntity100001930.
- Ajulemic_acid type Relation100031921.
- Ajulemic_acid type Substance100019613.
- Ajulemic_acid type Drug.
- Ajulemic_acid type DrugProduct.
- Ajulemic_acid type FunctionalSubstance.
- Ajulemic_acid comment "Ajulemic acid (AB-III-56, HU-239, IP-751, CPL 7075, CT-3, Resunab) is a synthetic cannabinoid derivative of the non-psychoactive THC metabolite 11-nor-9-carboxy-THC that shows useful analgesic and anti-inflammatory effects without causing a subjective "high". It is being developed for the treatment of neuropathic pain and inflammatory conditions such as arthritis.".
- Ajulemic_acid label "Acido ajulemico".
- Ajulemic_acid label "Ajulemic acid".
- Ajulemic_acid sameAs Acido_ajulemico.
- Ajulemic_acid sameAs m.02qtmfs.
- Ajulemic_acid sameAs Q3604498.
- Ajulemic_acid sameAs Q3604498.
- Ajulemic_acid sameAs Ajulemic_acid.
- Ajulemic_acid wasDerivedFrom Ajulemic_acid?oldid=602850702.
- Ajulemic_acid depiction Ajulemicacid.png.
- Ajulemic_acid isPrimaryTopicOf Ajulemic_acid.
