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- Alternative_splicing abstract "Alternative splicing is a regulated process during gene expression that results in a single gene coding for multiple proteins. In this process, particular exons of a gene may be included within, or excluded from, the final, processed messenger RNA (mRNA) produced from that gene. Consequently the proteins translated from alternatively spliced mRNAs will contain differences in their amino acid sequence and, often, in their biological functions (see Figure). Notably, alternative splicing allows the human genome to direct the synthesis of many more proteins than would be expected from its 20,000 protein-coding genes. Alternative splicing is sometimes termed differential splicing, but it does not increase gene expression.Alternative splicing occurs as a normal phenomenon in eukaryotes, where it greatly increases the biodiversity of proteins that can be encoded by the genome; in humans, ~95% of multiexonic genes are alternatively spliced. There are numerous modes of alternative splicing observed, of which the most common is exon skipping. In this mode, a particular exon may be included in mRNAs under some conditions or in particular tissues, and omitted from the mRNA in others.The production of alternatively spliced mRNAs is regulated by a system of trans-acting proteins that bind to cis-acting sites on the primary transcript itself. Such proteins include splicing activators that promote the usage of a particular splice site, and splicing repressors that reduce the usage of a particular site. Mechanisms of alternative splicing are highly variable, and new examples are constantly being found, particularly through the use of high-throughput techniques. Researchers hope to fully elucidate the regulatory systems involved in splicing, so that alternative splicing products from a given gene under particular conditions could be predicted by a "splicing code".Abnormal variations in splicing are also implicated in disease; a large proportion of human genetic disorders result from splicing variants. Abnormal splicing variants are also thought to contribute to the development of cancer, although such aberrant splicoforms are, under normal conditions, usually safeguarded and eliminated by a posttranscriptional quality control mechanism.".
- Alternative_splicing thumbnail DNA_alternative_splicing.gif?width=300.
- Alternative_splicing wikiPageExternalLink bip.umiacs.umd.edu:8080.
- Alternative_splicing wikiPageExternalLink index.html.
- Alternative_splicing wikiPageExternalLink 6837.
- Alternative_splicing wikiPageExternalLink www.dip.molmed.eu.
- Alternative_splicing wikiPageExternalLink www.stamms-lab.net.
- Alternative_splicing wikiPageID "209459".
- Alternative_splicing wikiPageRevisionID "605132004".
- Alternative_splicing hasPhotoCollection Alternative_splicing.
- Alternative_splicing subject Category:Gene_expression.
- Alternative_splicing subject Category:RNA_splicing.
- Alternative_splicing subject Category:Spliceosome.
- Alternative_splicing comment "Alternative splicing is a regulated process during gene expression that results in a single gene coding for multiple proteins. In this process, particular exons of a gene may be included within, or excluded from, the final, processed messenger RNA (mRNA) produced from that gene. Consequently the proteins translated from alternatively spliced mRNAs will contain differences in their amino acid sequence and, often, in their biological functions (see Figure).".
- Alternative_splicing label "Alternatieve splicing".
- Alternative_splicing label "Alternative splicing".
- Alternative_splicing label "Alternatives Spleißen".
- Alternative_splicing label "Splicing alternativo".
- Alternative_splicing label "Splicing alternativo".
- Alternative_splicing label "Splicing alternatywny".
- Alternative_splicing label "Альтернативный сплайсинг".
- Alternative_splicing label "選択的スプライシング".
- Alternative_splicing label "選擇性剪接".
- Alternative_splicing sameAs Alternativní_splicing.
- Alternative_splicing sameAs Alternatives_Spleißen.
- Alternative_splicing sameAs Splicing_alternativo.
- Alternative_splicing sameAs 選択的スプライシング.
- Alternative_splicing sameAs Alternatieve_splicing.
- Alternative_splicing sameAs Splicing_alternatywny.
- Alternative_splicing sameAs Splicing_alternativo.
- Alternative_splicing sameAs m.01drmz.
- Alternative_splicing sameAs Q1129238.
- Alternative_splicing sameAs Q1129238.
- Alternative_splicing wasDerivedFrom Alternative_splicing?oldid=605132004.
- Alternative_splicing depiction DNA_alternative_splicing.gif.
- Alternative_splicing isPrimaryTopicOf Alternative_splicing.
