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- Amylin_family abstract "In molecular biology, the amylin protein family or calcitonin/CGRP/IAPP protein family' is a family of proteins, which includes the precursors of calcitonin/calcitonin gene-related peptide (CGRP), islet amyloid polypeptide (IAPP) and adrenomedullin.Calcitonin is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones, alpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids, called calcitonin gene-related peptide (CGRP), beta type. CGRP induces vasodilatation in a variety of vessels, including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.Islet amyloid polypeptide (IAPP) (also known as diabetes-associated peptide (DAP), or amylin) is a peptide of 37 amino acids that selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Structurally, IAPP is closely related to CGRP.Two conserved cysteines in the N-terminal of these peptides are known to be involved in a disulfide bond. The C-terminal amino acid of all three peptides is amidated. xCxxxxxCxxxxxxxxxxxxxxxxxxxxxxxxxxxx-NH(2) | | Amide group +-----+".
- Amylin_family symbol "Calc_CGRP_IAPP".
- Amylin_family thumbnail PDB_2glh_EBI.jpg?width=300.
- Amylin_family wikiPageID "32180176".
- Amylin_family wikiPageRevisionID "590583893".
- Amylin_family caption "solution conformation of salmon calcitonin in sodium dodecyl sulfate micelles".
- Amylin_family hasPhotoCollection Amylin_family.
- Amylin_family interpro "IPR021116".
- Amylin_family name "Calc_CGRP_IAPP".
- Amylin_family opmFamily "276".
- Amylin_family opmProtein "2".
- Amylin_family pfam "PF00214".
- Amylin_family prosite "PDOC00231".
- Amylin_family scop "1".
- Amylin_family symbol "Calc_CGRP_IAPP".
- Amylin_family tcdb "1".
- Amylin_family subject Category:Peptide_hormones.
- Amylin_family subject Category:Protein_families.
- Amylin_family type Abstraction100002137.
- Amylin_family type Family108078020.
- Amylin_family type Group100031264.
- Amylin_family type Organization108008335.
- Amylin_family type ProteinFamilies.
- Amylin_family type SocialGroup107950920.
- Amylin_family type Unit108189659.
- Amylin_family type YagoLegalActor.
- Amylin_family type YagoLegalActorGeo.
- Amylin_family type YagoPermanentlyLocatedEntity.
- Amylin_family type Biomolecule.
- Amylin_family type Protein.
- Amylin_family type BiologicalObject.
- Amylin_family comment "In molecular biology, the amylin protein family or calcitonin/CGRP/IAPP protein family' is a family of proteins, which includes the precursors of calcitonin/calcitonin gene-related peptide (CGRP), islet amyloid polypeptide (IAPP) and adrenomedullin.Calcitonin is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones, alpha type.".
- Amylin_family label "Amylin family".
- Amylin_family sameAs m.0gx_6jp.
- Amylin_family sameAs Q4749531.
- Amylin_family sameAs Q4749531.
- Amylin_family sameAs Amylin_family.
- Amylin_family wasDerivedFrom Amylin_family?oldid=590583893.
- Amylin_family depiction PDB_2glh_EBI.jpg.
- Amylin_family isPrimaryTopicOf Amylin_family.
