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- Apaziquone abstract "Apaziquone (EOquin) is an indolequinone that is a bioreductive prodrug and a chemical analog of the older chemotherapeutic agent mitomycin C. In hypoxic cells, such as those on the inner surface of the urinary bladder, apaziquone is converted to active metabolites by intracellular reductases. The active metabolites alkylate DNA and lead to apoptotic cell death. This activity is preferentially expressed in neoplastic cells.After administration of apaziquone directly into the urinary bladder, the drug and its active metabolite were not detected in plasma, and there were no systemic side effectsApaziquone has been applied in clinical studies sponsored by Spectrum Pharmaceuticals and Allergan, Inc. for the treatment of superficial (non-muscle invasive) bladder cancer. Approximately 70% of all newly diagnosed patients with bladder cancer have non-muscle invasive bladder cancer and over one million patients in the United States and Europe are affected by the disease. The US Food and Drug Administration (FDA) has granted Fast Track review status to apaziquone for this indication.".
- Apaziquone atcPrefix "none".
- Apaziquone casNumber "114560-48-4".
- Apaziquone fdaUniiCode "H464ZO600O".
- Apaziquone iupacName "(E)-5-(1-Azirinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione".
- Apaziquone pubchem "5813717".
- Apaziquone thumbnail Apaziquone.svg?width=300.
- Apaziquone wikiPageID "23150392".
- Apaziquone wikiPageRevisionID "590598906".
- Apaziquone atcPrefix "none".
- Apaziquone c "15".
- Apaziquone casNumber "114560".
- Apaziquone chembl "73822".
- Apaziquone chemspiderid "4710342".
- Apaziquone h "16".
- Apaziquone hasPhotoCollection Apaziquone.
- Apaziquone inchi "1".
- Apaziquone inchikey "MXPOCMVWFLDDLZ-NSCUHMNNSA-N".
- Apaziquone iupacName "-5".
- Apaziquone kegg "D02965".
- Apaziquone molecularWeight "288".
- Apaziquone n "2".
- Apaziquone o "4".
- Apaziquone pubchem "5813717".
- Apaziquone smiles "Cn1c/C=C/CO".
- Apaziquone stdinchi "1".
- Apaziquone stdinchikey "MXPOCMVWFLDDLZ-NSCUHMNNSA-N".
- Apaziquone unii "H464ZO600O".
- Apaziquone verifiedfields "changed".
- Apaziquone verifiedrevid "457134883".
- Apaziquone subject Category:Alcohols.
- Apaziquone subject Category:Antineoplastic_drugs.
- Apaziquone subject Category:Aziridines.
- Apaziquone subject Category:Indoles.
- Apaziquone subject Category:Quinones.
- Apaziquone type Abstraction100002137.
- Apaziquone type Agent114778436.
- Apaziquone type Alcohol107884567.
- Apaziquone type Alcohols.
- Apaziquone type Beverage107881800.
- Apaziquone type CausalAgent100007347.
- Apaziquone type Chemical114806838.
- Apaziquone type Compound114818238.
- Apaziquone type Drug103247620.
- Apaziquone type DrugOfAbuse103248958.
- Apaziquone type Fluid114939900.
- Apaziquone type Food100021265.
- Apaziquone type Liquid114940386.
- Apaziquone type Material114580897.
- Apaziquone type Matter100020827.
- Apaziquone type Part113809207.
- Apaziquone type PhysicalEntity100001930.
- Apaziquone type Quinone115000973.
- Apaziquone type Quinones.
- Apaziquone type Relation100031921.
- Apaziquone type Substance100019613.
- Apaziquone type Substance100020090.
- Apaziquone type Drug.
- Apaziquone type DrugProduct.
- Apaziquone type FunctionalSubstance.
- Apaziquone comment "Apaziquone (EOquin) is an indolequinone that is a bioreductive prodrug and a chemical analog of the older chemotherapeutic agent mitomycin C. In hypoxic cells, such as those on the inner surface of the urinary bladder, apaziquone is converted to active metabolites by intracellular reductases. The active metabolites alkylate DNA and lead to apoptotic cell death.".
- Apaziquone label "Apaziquone".
- Apaziquone sameAs m.064kh46.
- Apaziquone sameAs Q4779259.
- Apaziquone sameAs Q4779259.
- Apaziquone sameAs Apaziquone.
- Apaziquone wasDerivedFrom Apaziquone?oldid=590598906.
- Apaziquone depiction Apaziquone.svg.
- Apaziquone isPrimaryTopicOf Apaziquone.