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- Aplindore abstract "Aplindore (DAB-452) is a drug which acts as a partial agonist selective for the dopamine receptor D2. It is being developed by the pharmaceutical company Neurogen as a treatment for Parkinson's disease and restless legs syndrome.On December 23rd Neurogen was acquired by Ligand Pharmaceuticals. Rights to Aplindore were given to Ligand around time of merger. As of 2008, Phase II was completed and Ligand. Upon reviewing company website (Ligand.com) this drug is currently not listed at the moment due to several programs already partnered with GSK. GSK holds a significant share of the drug RLS drug programs on the market with Requip XR and the recent FDA approval of Horizant. To prevent any direct competition and losing strong ties with GSK, Aplindore is not listed at the moment on Lidgand website. If this medication were to reach phase III, this could adversely effect Ligand`s portfolio of partnered and unpartnered assets. By electing not to list the drug on company website, Ligand maintains the appearance that they are "currently actively seeking a partner" when a potential investor inquirers about drug development via email.".
- Aplindore atcPrefix "none".
- Aplindore casNumber "189681-71-8".
- Aplindore fdaUniiCode "Q5O76TA0ML".
- Aplindore iupacName "(2S)-2-[(phenylmethylamino)methyl]-2,3,7,9-tetrahydro-[1,4]dioxino[3,2-e]indol-8-one".
- Aplindore pubchem "158784".
- Aplindore thumbnail Aplindore.png?width=300.
- Aplindore wikiPageExternalLink article_news.asp?guid=E6E77319-B0D6-4E6A-9288-DD43A553D2F9.
- Aplindore wikiPageID "19215508".
- Aplindore wikiPageRevisionID "590231168".
- Aplindore atcPrefix "none".
- Aplindore c "18".
- Aplindore casNumber "189681".
- Aplindore chemspiderid "139676".
- Aplindore h "18".
- Aplindore hasPhotoCollection Aplindore.
- Aplindore inchi "1".
- Aplindore inchikey "DYJIKHYBKVODAC-ZDUSSCGKBE".
- Aplindore iupacName "-2".
- Aplindore kegg "D03214".
- Aplindore molecularWeight "310.346".
- Aplindore n "2".
- Aplindore o "3".
- Aplindore pubchem "158784".
- Aplindore pubchem "6440763".
- Aplindore smiles "c4ccccc4CNCCOc1c2cccc1CC3=O".
- Aplindore stdinchi "1".
- Aplindore stdinchikey "DYJIKHYBKVODAC-ZDUSSCGKSA-N".
- Aplindore unii "Q5O76TA0ML".
- Aplindore verifiedrevid "455102698".
- Aplindore subject Category:Amines.
- Aplindore subject Category:Benzodioxins.
- Aplindore subject Category:Dopamine_agonists.
- Aplindore subject Category:Lactams.
- Aplindore type Abstraction100002137.
- Aplindore type AliphaticCompound114601294.
- Aplindore type Amine114739004.
- Aplindore type Amines.
- Aplindore type Chemical114806838.
- Aplindore type Compound114818238.
- Aplindore type Material114580897.
- Aplindore type Matter100020827.
- Aplindore type MethaneSeries114951377.
- Aplindore type OrganicCompound114727670.
- Aplindore type Part113809207.
- Aplindore type PhysicalEntity100001930.
- Aplindore type Relation100031921.
- Aplindore type Substance100019613.
- Aplindore type Drug.
- Aplindore type DrugProduct.
- Aplindore type FunctionalSubstance.
- Aplindore comment "Aplindore (DAB-452) is a drug which acts as a partial agonist selective for the dopamine receptor D2. It is being developed by the pharmaceutical company Neurogen as a treatment for Parkinson's disease and restless legs syndrome.On December 23rd Neurogen was acquired by Ligand Pharmaceuticals. Rights to Aplindore were given to Ligand around time of merger. As of 2008, Phase II was completed and Ligand.".
- Aplindore label "Aplindore".
- Aplindore label "Aplindore".
- Aplindore sameAs Aplindore.
- Aplindore sameAs m.04lfd7b.
- Aplindore sameAs Q4779987.
- Aplindore sameAs Q4779987.
- Aplindore sameAs Aplindore.
- Aplindore wasDerivedFrom Aplindore?oldid=590231168.
- Aplindore depiction Aplindore.png.
- Aplindore isPrimaryTopicOf Aplindore.