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- Apoptosome abstract "The apoptosome is a large quaternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can vary from DNA damage and viral infection to developmental cues such as those leading to the degradation of a tadpole's tail.In mammalian cells, once cytochrome c is released, it binds to the cytosolic protein Apaf-1 to facilitate the formation of apoptosome. An early biochemical study suggests a two-to-one ratio of cytochrome c to apaf-1 for apoptosome formation. However, recent structural studies suggest the cytochrome c to apaf-1 ratio is one-to-one. It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. The mammalian apoptosome had never been crystallized, but a human APAF-1/cytochrome-c apoptosome has been imaged at lower (2 nm) resolution by cryogenic transmission electron microscopy 10 years ago, revealing a wheel-like particle with 7-fold symmetry. Recently, a medium resolution (9.5 Ångström) structure of human apoptosome was also solved by cryo-electron microscopy, which allows unambiguous inference for positions of all the APAF-1 domains (CARD, NBARC and WD40) and cytochrome c. Once formed, the apoptosome can then recruit and activate the inactive pro-caspase-9. Once activated, this initiator caspase can then activate effector caspases and trigger a cascade of events leading to apoptosis.".
- Apoptosome thumbnail Hapop.jpg?width=300.
- Apoptosome wikiPageID "3736715".
- Apoptosome wikiPageRevisionID "542405539".
- Apoptosome hasPhotoCollection Apoptosome.
- Apoptosome subject Category:Apoptosis.
- Apoptosome subject Category:Organelles.
- Apoptosome subject Category:Programmed_cell_death.
- Apoptosome type BodyPart105220461.
- Apoptosome type Organ105297523.
- Apoptosome type Organelle105445668.
- Apoptosome type Organelles.
- Apoptosome type Part109385911.
- Apoptosome type PhysicalEntity100001930.
- Apoptosome type Thing100002452.
- Apoptosome comment "The apoptosome is a large quaternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus.".
- Apoptosome label "Apoptosoma".
- Apoptosome label "Apoptosome".
- Apoptosome label "Apoptosome".
- Apoptosome label "Apoptosoom".
- Apoptosome label "Apoptossomo".
- Apoptosome label "Апоптосома".
- Apoptosome sameAs Apoptosoma.
- Apoptosome sameAs Apoptosome.
- Apoptosome sameAs Apoptosoom.
- Apoptosome sameAs Apoptossomo.
- Apoptosome sameAs m.09y4hm.
- Apoptosome sameAs Q2061363.
- Apoptosome sameAs Q2061363.
- Apoptosome sameAs Apoptosome.
- Apoptosome wasDerivedFrom Apoptosome?oldid=542405539.
- Apoptosome depiction Hapop.jpg.
- Apoptosome isPrimaryTopicOf Apoptosome.
