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- Aryl_hydrocarbon_receptor_nuclear_translocator abstract "The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.The aryl hydrocarbon receptor (AhR) is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the aryl hydrocarbon receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound AhR to xenobiotic responsive elements in the promoters of genes for these enzymes.".
- Aryl_hydrocarbon_receptor_nuclear_translocator entrezgene "405".
- Aryl_hydrocarbon_receptor_nuclear_translocator wikiPageID "5987626".
- Aryl_hydrocarbon_receptor_nuclear_translocator wikiPageRevisionID "601800464".
- Aryl_hydrocarbon_receptor_nuclear_translocator hasPhotoCollection Aryl_hydrocarbon_receptor_nuclear_translocator.
- Aryl_hydrocarbon_receptor_nuclear_translocator subject Category:Transcription_factors.
- Aryl_hydrocarbon_receptor_nuclear_translocator type Abstraction100002137.
- Aryl_hydrocarbon_receptor_nuclear_translocator type Beginning107290905.
- Aryl_hydrocarbon_receptor_nuclear_translocator type Cause107326557.
- Aryl_hydrocarbon_receptor_nuclear_translocator type Event100029378.
- Aryl_hydrocarbon_receptor_nuclear_translocator type Factor107327805.
- Aryl_hydrocarbon_receptor_nuclear_translocator type Happening107283608.
- Aryl_hydrocarbon_receptor_nuclear_translocator type Origin107323922.
- Aryl_hydrocarbon_receptor_nuclear_translocator type PsychologicalFeature100023100.
- Aryl_hydrocarbon_receptor_nuclear_translocator type TranscriptionFactors.
- Aryl_hydrocarbon_receptor_nuclear_translocator type YagoPermanentlyLocatedEntity.
- Aryl_hydrocarbon_receptor_nuclear_translocator type Biomolecule.
- Aryl_hydrocarbon_receptor_nuclear_translocator type Protein.
- Aryl_hydrocarbon_receptor_nuclear_translocator type BiologicalObject.
- Aryl_hydrocarbon_receptor_nuclear_translocator comment "The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia.".
- Aryl_hydrocarbon_receptor_nuclear_translocator label "Aryl hydrocarbon receptor nuclear translocator".
- Aryl_hydrocarbon_receptor_nuclear_translocator sameAs m.02p9xwb.
- Aryl_hydrocarbon_receptor_nuclear_translocator sameAs Q4802695.
- Aryl_hydrocarbon_receptor_nuclear_translocator sameAs Q4802695.
- Aryl_hydrocarbon_receptor_nuclear_translocator sameAs ARNT.
- Aryl_hydrocarbon_receptor_nuclear_translocator sameAs Aryl_hydrocarbon_receptor_nuclear_translocator.
- Aryl_hydrocarbon_receptor_nuclear_translocator wasDerivedFrom Aryl_hydrocarbon_receptor_nuclear_translocator?oldid=601800464.
- Aryl_hydrocarbon_receptor_nuclear_translocator isPrimaryTopicOf Aryl_hydrocarbon_receptor_nuclear_translocator.