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- Ascomycin abstract "Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It can be used to treat autoimmune diseases and skin diseases, and can help prevent rejection after an organ transplant.Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines. Additionally, ascomycin preferentially inhibits the activation of mast cells, an important cellular component of the atopic response. Ascomycin produces a more selective immunomodulatory effect in that it inhibits the elicitation phase of allergic contact dermatitis but does not impair the primary immune response when administered systemically.Ascomycin is produced by the fermentation of Streptomyces hygroscopicus.".
- Ascomycin atcPrefix "none".
- Ascomycin casNumber "11011-38-4".
- Ascomycin chEBI "29582".
- Ascomycin iupacName "(3S,​4R,​5S,​8R,​9Z,​12S,​14S,​15R,​16S,​18R,​19R,​26aS)-​8-​ethyl-​5,​19-​dihydroxy-​3-​{(E)-​2-​[(1R,​3R,​4R)-​4-​hydroxy-​3-​methoxycyclohexyl]-​1-​methylvinyl}-​14,​16-​dimethoxy-​4,​10,​12,​18-​tetramethyl-​4,​5,​6,​8,​11,​12,​13,​14,​15,​16,​17,​18,​19,​24,​25,​26,​26a-​heptadecahydro-​3H-​15,​19-​epoxypyrido[2,1-c]​[1,4]oxazacyclotriclosine-1,​7,​20,​21(23H)-​tetrone".
- Ascomycin pubchem "5282071".
- Ascomycin thumbnail Ascomycin_structure.png?width=300.
- Ascomycin wikiPageExternalLink 1728_55822.htm.
- Ascomycin wikiPageID "3933000".
- Ascomycin wikiPageRevisionID "604588335".
- Ascomycin atcPrefix "none".
- Ascomycin c "43".
- Ascomycin casNumber "11011".
- Ascomycin chebi "29582".
- Ascomycin chembl "8597".
- Ascomycin chemspiderid "4445297".
- Ascomycin h "69".
- Ascomycin hasPhotoCollection Ascomycin.
- Ascomycin iupacName "-​8-​ethyl-​5,​19-​dihydroxy-​3-​{-​2-​[-​4-​hydroxy-​3-​methoxycyclohexyl]-​1-​methylvinyl}-​14,​16-​dimethoxy-​4,​10,​12,​18-​tetramethyl-​4,​5,​6,​8,​11,​12,​13,​14,​15,​16,​17,​18,​19,​24,​25,​26,​26a-​heptadecahydro-​3H-​15,​19-​epoxypyrido[2,1-c]​[1,4]oxazacyclotriclosine-1,​7,​20,​21-​tetrone".
- Ascomycin molecularWeight "792.01".
- Ascomycin n "1".
- Ascomycin o "12".
- Ascomycin pubchem "5282071".
- Ascomycin smiles "O=C3CN1CCCC[C@H]1CO[C@H][C@H][C@@H]CC[C@@H]CC".
- Ascomycin stdinchi "1".
- Ascomycin stdinchikey "ZDQSOHOQTUFQEM-NURRSENYSA-N".
- Ascomycin synonyms "(17-ethyl-1,14-dihydroxy-12-[2--1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone)".
- Ascomycin verifiedfields "changed".
- Ascomycin verifiedrevid "457820106".
- Ascomycin subject Category:Immunosuppressants.
- Ascomycin type Agent114778436.
- Ascomycin type CausalAgent100007347.
- Ascomycin type Drug103247620.
- Ascomycin type Immunosuppressant103562958.
- Ascomycin type Immunosuppressants.
- Ascomycin type Matter100020827.
- Ascomycin type Medicine103740161.
- Ascomycin type PhysicalEntity100001930.
- Ascomycin type Substance100020090.
- Ascomycin type Drug.
- Ascomycin type DrugProduct.
- Ascomycin type FunctionalSubstance.
- Ascomycin comment "Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It can be used to treat autoimmune diseases and skin diseases, and can help prevent rejection after an organ transplant.Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines.".
- Ascomycin label "Ascomycin".
- Ascomycin sameAs m.0b7fln.
- Ascomycin sameAs Q4803998.
- Ascomycin sameAs Q4803998.
- Ascomycin sameAs Ascomycin.
- Ascomycin wasDerivedFrom Ascomycin?oldid=604588335.
- Ascomycin depiction Ascomycin_structure.png.
- Ascomycin isPrimaryTopicOf Ascomycin.
