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- Autoinducer-2 abstract "Autoinducer-2 (AI-2), a furanosyl borate diester, is a member of a family of signaling molecules used in quorum sensing. AI-2 is unique in that it is one of only a few known biomolecules incorporating boron. First identified in the marine bacterium Vibrio harveyi, AI-2 is produced and recognized by many Gram-negative and Gram-positive bacteria. AI-2 is synthesized by the reaction of 1-deoxy-3-dehydro-D-ribulose with boric acid.AI-2 is sensed by the Lsr transport cassette and is actively transported into the cell, where it is phosphorylated by LsrK . Then, Phospho-AI-2 binds the transcriptional repressor protein, LsrR, which subsequently is released from the promoter/operator region of the lsr operon – and transcription of the lsr genes is initiated. AI-2 signalling is also regulated by glucose and cAMP/CRP via the lsr operon. In the presence of glucose, low levels of cAMP/CRP result in almost no lsr operon (lsrABCDFG) expression. Without glucose, cAMP-CRP is needed to stimulate the lsr expression, while LsrR represses its expression in the absence of the inducer, phospho-AI-2. As AI-2 accumulates, more AI-2 is taken in via LsrABCD, phosphorylated via LsrK, and the lsr transcription is de-repressed, enabling even more AI-2 uptake.Doubts have been expressed regarding AI-2's status as a universal signal. The gene responsible for its production is the widespread luxS; this gene has an important role in the recycling of S-adenosyl-L-methionine, with AI-2 being a metabolic by-product of that process. While it is certainly true that some bacteria respond to AI-2, it is not yet clear that it is always being produced for purposes of signalling.".
- Autoinducer-2 iupacName "(3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide)".
- Autoinducer-2 thumbnail AI-2.png?width=300.
- Autoinducer-2 wikiPageID "20015565".
- Autoinducer-2 wikiPageRevisionID "578614814".
- Autoinducer-2 hasPhotoCollection Autoinducer-2.
- Autoinducer-2 imagefile "AI-2.png".
- Autoinducer-2 imagename "Autoinducer-2".
- Autoinducer-2 imagesize "250".
- Autoinducer-2 iupacname "-2266".
- Autoinducer-2 name "Autoinducer-2".
- Autoinducer-2 othernames "Dihydroxy[-2-methyldihydro-]".
- Autoinducer-2 target "LsrK".
- Autoinducer-2 type "phosphorylated_by".
- Autoinducer-2 verifiedrevid "458783070".
- Autoinducer-2 watchedfields "changed".
- Autoinducer-2 subject Category:Borate_esters.
- Autoinducer-2 subject Category:Cell_biology.
- Autoinducer-2 subject Category:Cell_communication.
- Autoinducer-2 subject Category:Cell_signaling.
- Autoinducer-2 subject Category:Signal_transduction.
- Autoinducer-2 type ChemicalCompound.
- Autoinducer-2 type ChemicalSubstance.
- Autoinducer-2 type ChemicalSubstanceType.
- Autoinducer-2 type ChemicalObject.
- Autoinducer-2 type Thing.
- Autoinducer-2 comment "Autoinducer-2 (AI-2), a furanosyl borate diester, is a member of a family of signaling molecules used in quorum sensing. AI-2 is unique in that it is one of only a few known biomolecules incorporating boron. First identified in the marine bacterium Vibrio harveyi, AI-2 is produced and recognized by many Gram-negative and Gram-positive bacteria.".
- Autoinducer-2 label "Autoinducer-2".
- Autoinducer-2 sameAs m.04y7mp3.
- Autoinducer-2 sameAs Q4826351.
- Autoinducer-2 sameAs Q4826351.
- Autoinducer-2 wasDerivedFrom Autoinducer-2?oldid=578614814.
- Autoinducer-2 depiction AI-2.png.
- Autoinducer-2 isPrimaryTopicOf Autoinducer-2.
- Autoinducer-2 name "Autoinducer-2".
