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- B3GALT5 abstract "Beta-1,3-galactosyltransferase 5 is an enzyme that in humans is encoded by the B3GALT5 gene.This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes the most probable candidate for synthesis of the type 1 Lewis antigens which are frequently found to be elevated in gastrointestinal and pancreatic cancers. The encoded protein is inactive with N-linked glycoproteins and functions in mucin glycosylation. Five transcript variants have been described which differ in the 5' UTR. All transcript variants encode an identical protein.".
- B3GALT5 entrezgene "10317".
- B3GALT5 wikiPageID "15182220".
- B3GALT5 wikiPageRevisionID "590726072".
- B3GALT5 hasPhotoCollection B3GALT5.
- B3GALT5 requireManualInspection "no".
- B3GALT5 summaryText "This gene is a member of the beta-1,3-galactosyltransferase gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates and different acceptor sugars . The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes . This gene encodes the most probable candidate for synthesis of the type 1 Lewis antigens which are frequently found to be elevated in gastrointestinal and pancreatic cancers. The encoded protein is inactive with N-linked glycoproteins and functions in mucin glycosylation. Five transcript variants have been described which differ in the 5' UTR. All transcript variants encode an identical protein.".
- B3GALT5 updateCitations "yes".
- B3GALT5 updatePage "yes".
- B3GALT5 updateProteinBox "yes".
- B3GALT5 updateSummary "yes".
- B3GALT5 type Biomolecule.
- B3GALT5 type Protein.
- B3GALT5 type BiologicalObject.
- B3GALT5 comment "Beta-1,3-galactosyltransferase 5 is an enzyme that in humans is encoded by the B3GALT5 gene.This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine).".
- B3GALT5 label "B3GALT5".
- B3GALT5 sameAs m.03hl3nd.
- B3GALT5 sameAs Q4834401.
- B3GALT5 sameAs Q4834401.
- B3GALT5 wasDerivedFrom B3GALT5?oldid=590726072.
- B3GALT5 isPrimaryTopicOf B3GALT5.