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- BRL-15,572 abstract "BRL-15,572 is a drug which acts as a selective antagonist for the serotonin receptor subtype 5-HT1D, with around 60x selectivity over other related receptors. The 5-HT1D receptor has a very similar pharmacology to the closely related 5-HT1B receptor, and most older ligands for these receptors bind to both subtypes with approximately equal affinity, so development of compounds such as BRL-15572 which are able to selectively block the 5-HT1D subtype while leaving 5-HT1B unaffected, have been a significant advance which has helped scientists in researching the function of these serotonin receptor subtypes. One function of the 5-HT1D receptor this research has revealed is its role in modulating release of the neurotransmitter glutamate in the brain, as well as functions in regulation of cerebral blood pressure which are important in the pathogenesis of migraine headaches.".
- BRL-15,572 atcPrefix "none".
- BRL-15,572 casNumber "193611-72-2".
- BRL-15,572 iupacName "3-(4-(4-chlorophenyl)piperazin-1-yl)-1,1-diphenyl-2-propanol".
- BRL-15,572 pubchem "3654103".
- BRL-15,572 thumbnail BRL-15572_structure.png?width=300.
- BRL-15,572 wikiPageID "20768534".
- BRL-15,572 wikiPageRevisionID "545522813".
- BRL-15,572 atcPrefix "none".
- BRL-15,572 c "25".
- BRL-15,572 casNumber "193611".
- BRL-15,572 chembl "534232".
- BRL-15,572 chemspiderid "2887678".
- BRL-15,572 cl "1".
- BRL-15,572 h "27".
- BRL-15,572 hasPhotoCollection BRL-15,572.
- BRL-15,572 inchi "1".
- BRL-15,572 inchikey "QJHCTHPYUOXOGM-UHFFFAOYAJ".
- BRL-15,572 iupacName "3".
- BRL-15,572 iupharLigand "10".
- BRL-15,572 molecularWeight "406.947".
- BRL-15,572 n "2".
- BRL-15,572 o "1".
- BRL-15,572 pubchem "3654103".
- BRL-15,572 smiles "Clc2ccccN1CCNCCCc4ccccc4".
- BRL-15,572 verifiedfields "changed".
- BRL-15,572 verifiedrevid "407723615".
- BRL-15,572 subject Category:5-HT1D_antagonists.
- BRL-15,572 subject Category:Alcohols.
- BRL-15,572 subject Category:Organochlorides.
- BRL-15,572 subject Category:Piperazines.
- BRL-15,572 type Drug.
- BRL-15,572 type FunctionalSubstance.
- BRL-15,572 comment "BRL-15,572 is a drug which acts as a selective antagonist for the serotonin receptor subtype 5-HT1D, with around 60x selectivity over other related receptors.".
- BRL-15,572 label "BRL-15,572".
- BRL-15,572 sameAs m.056q4cm.
- BRL-15,572 sameAs Q4836376.
- BRL-15,572 sameAs Q4836376.
- BRL-15,572 wasDerivedFrom BRL-15,572?oldid=545522813.
- BRL-15,572 depiction BRL-15572_structure.png.
- BRL-15,572 isPrimaryTopicOf BRL-15,572.
