Matches in DBpedia 2014 for { <http://dbpedia.org/resource/BW_A444> ?p ?o. }
Showing items 1 to 28 of
28
with 100 items per page.
- BW_A444 abstract "BW A444U was an experimental neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, intended to be used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It was synthesized and developed in the early 1980s.BW A444U represented the first generation of tetrahydroisoquinolinium neuromuscular-blocking drugs that are nicotinic acetylcholine receptor anatagonists. It was an intermediate-duration non-depolarizing neuromuscular-blocking drug or skeletal muscle relaxant. It was synthesized by Mary M. Jackson and James C. Wisowaty, PhD (both chemists within the Chemical Development Laboratories at Burroughs Wellcome Co., Research Triangle Park, NC) in collaboration with John J. Savarese MD (who at the time was an anesthesiologist in the Dept. of Anesthesia, Harvard Medical School at the Massachusetts General Hospital, Boston, MA).The drug was tested clinically in the early 1980s, and quickly abandoned from further clinical development after a single clinical study, owing primarily to undesirable effects of histamine release when administered at clinically relevant doses.".
- BW_A444 casNumber "73909-73-6".
- BW_A444 iupacName "2,2'-[1,4-phenylenebis[(1-oxo-2-propene-3,1-diyl)oxy-3,1-propanediyl]]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium] dichloride".
- BW_A444 thumbnail BW_A444U.svg?width=300.
- BW_A444 wikiPageID "30937751".
- BW_A444 wikiPageRevisionID "580004290".
- BW_A444 c "62".
- BW_A444 casNumber "73909".
- BW_A444 cl "2".
- BW_A444 h "78".
- BW_A444 hasPhotoCollection BW_A444.
- BW_A444 iupacName "22".
- BW_A444 legalStatus "Investigational".
- BW_A444 molecularWeight "1146.19".
- BW_A444 n "2".
- BW_A444 o "14".
- BW_A444 width "250".
- BW_A444 subject Category:Muscle_relaxants.
- BW_A444 type Drug.
- BW_A444 type FunctionalSubstance.
- BW_A444 comment "BW A444U was an experimental neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, intended to be used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.".
- BW_A444 label "BW A444".
- BW_A444 sameAs m.0gg4tt4.
- BW_A444 sameAs Q4836854.
- BW_A444 sameAs Q4836854.
- BW_A444 wasDerivedFrom BW_A444?oldid=580004290.
- BW_A444 depiction BW_A444U.svg.
- BW_A444 isPrimaryTopicOf BW_A444.
