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- Barbiturate_dependence abstract "With regular use of barbiturates, barbiturate dependence develops. This in turn may lead to a need for increasing doses of the drug to get the original desired pharmacological or therapeutic effect. Barbiturate use can lead to both addiction and physical dependence, and as such they have a high potential for abuse. Psychological addiction to barbiturates can develop quickly. The GABAA receptor, one of barbiturates' main sites of action, is thought to play a pivotal role in the development of tolerance to and dependence on barbiturates, as well as the euphoric "high" that results from their abuse. The mechanism by which barbiturate tolerance develops is believed to be different from that of ethanol or benzodiazepines, even though these drugs have been shown to exhibit cross-tolerance with each other. The management of a physical dependence on barbiturates is stabilisation on the long-acting barbiturate phenobarbital followed by a gradual titration down of dose. The slowly eliminated phenobarbital lessens the severity of the withdrawal syndrome and reduces the chances of serious barbiturate withdrawal effects such as seizures. Antipsychotics are not recommended for barbiturate withdrawal (or other CNS depressant withdrawal states) especially clozapine, olanzapine or low potency phenothiazines e.g. chlorpromazine as they lower the seizure threshold and can worsen withdrawal effects; if used extreme caution is required.".
- Barbiturate_dependence icd10 "F13.2".
- Barbiturate_dependence icd9 "304.1".
- Barbiturate_dependence wikiPageID "26983756".
- Barbiturate_dependence wikiPageRevisionID "596029036".
- Barbiturate_dependence hasPhotoCollection Barbiturate_dependence.
- Barbiturate_dependence icd "304.1".
- Barbiturate_dependence icd "F13.2".
- Barbiturate_dependence name "Barbiturate dependence".
- Barbiturate_dependence subject Category:Barbiturates.
- Barbiturate_dependence subject Category:Substance_dependence.
- Barbiturate_dependence type Abstraction100002137.
- Barbiturate_dependence type Attribute100024264.
- Barbiturate_dependence type Condition113920835.
- Barbiturate_dependence type Disease114070360.
- Barbiturate_dependence type IllHealth114052046.
- Barbiturate_dependence type Illness114061805.
- Barbiturate_dependence type PathologicalState114051917.
- Barbiturate_dependence type PhysicalCondition114034177.
- Barbiturate_dependence type State100024720.
- Barbiturate_dependence type Disease.
- Barbiturate_dependence type Situation.
- Barbiturate_dependence comment "With regular use of barbiturates, barbiturate dependence develops. This in turn may lead to a need for increasing doses of the drug to get the original desired pharmacological or therapeutic effect. Barbiturate use can lead to both addiction and physical dependence, and as such they have a high potential for abuse. Psychological addiction to barbiturates can develop quickly.".
- Barbiturate_dependence label "Barbiturate dependence".
- Barbiturate_dependence label "Барбитуризм".
- Barbiturate_dependence label "バルビツール酸系依存".
- Barbiturate_dependence sameAs バルビツール酸系依存.
- Barbiturate_dependence sameAs m.0bs3c19.
- Barbiturate_dependence sameAs Q4261984.
- Barbiturate_dependence sameAs Q4261984.
- Barbiturate_dependence sameAs Barbiturate_dependence.
- Barbiturate_dependence wasDerivedFrom Barbiturate_dependence?oldid=596029036.
- Barbiturate_dependence isPrimaryTopicOf Barbiturate_dependence.
- Barbiturate_dependence name "Barbiturate dependence".