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- Barbituric_acid abstract "Barbituric acid or malonylurea or 6-hydroxyuracil is an organic compound based on a pyrimidine heterocyclic skeleton. It is an odorless powder soluble in water. Barbituric acid is the parent compound of barbiturate drugs, although barbituric acid itself is not pharmacologically active. The compound was discovered by the German chemist Adolf von Baeyer on December 4, 1864, the feast of Saint Barbara (who gave the compound its namesake), by combining urea and malonic acid in a condensation reaction. Malonic acid has since been replaced by diethyl malonate, as using the ester avoids the problem of having to deal with the acidity of the carboxylic acid and its unreactive carboxylate.The α-carbon has a reactive hydrogen atom and is quite acidic (pKa = 4.01) even for a diketone species (cf. dimedone with pKa 5.23 and acetylacetone with pKa 8.95) because of the additional aromatic stabilisation of the carbanion. Using the Knoevenagel condensation reaction, barbituric acid can form a large variety of barbiturate drugs that behave as central nervous system depressants.Barbituric acid is used in synthesis of riboflavin[citation needed].As of 2007, more than 2550 barbiturates and related compounds have been synthesised, with 50 to 55 in clinical use around the world at present. The first to be used in medicine was barbital (Veronal) starting in 1903, and the second, phenobarbitone a.k.a. phenobarbital was first marketed in 1912.".
- Barbituric_acid iupacName "pyrimidine-2,4,6(1H,3H,5H)-trione".
- Barbituric_acid thumbnail Barbituric_acid.png?width=300.
- Barbituric_acid wikiPageExternalLink b0300.htm.
- Barbituric_acid wikiPageID "1674382".
- Barbituric_acid wikiPageRevisionID "606427393".
- Barbituric_acid hasPhotoCollection Barbituric_acid.
- Barbituric_acid imagefilel "Barbituric acid.png".
- Barbituric_acid imagefiler "Barbituric-acid-3D-balls.png".
- Barbituric_acid iupacname "pyrimidine-2,4,6-trione".
- Barbituric_acid othernames "246".
- Barbituric_acid verifiedrevid "443412797".
- Barbituric_acid subject Category:Barbiturates.
- Barbituric_acid subject Category:Pyrimidines.
- Barbituric_acid type ChemicalCompound.
- Barbituric_acid type ChemicalSubstance.
- Barbituric_acid type ChemicalSubstanceType.
- Barbituric_acid type ChemicalObject.
- Barbituric_acid type Thing.
- Barbituric_acid comment "Barbituric acid or malonylurea or 6-hydroxyuracil is an organic compound based on a pyrimidine heterocyclic skeleton. It is an odorless powder soluble in water. Barbituric acid is the parent compound of barbiturate drugs, although barbituric acid itself is not pharmacologically active.".
- Barbituric_acid label "Acide barbiturique".
- Barbituric_acid label "Acido barbiturico".
- Barbituric_acid label "Barbituric acid".
- Barbituric_acid label "Barbitursäure".
- Barbituric_acid label "Barbituurzuur".
- Barbituric_acid label "Kwas barbiturowy".
- Barbituric_acid label "Ácido barbitúrico".
- Barbituric_acid label "Ácido barbitúrico".
- Barbituric_acid label "Барбитуровая кислота".
- Barbituric_acid label "バルビツール酸".
- Barbituric_acid label "巴比妥酸".
- Barbituric_acid sameAs Kyselina_barbiturová.
- Barbituric_acid sameAs Barbitursäure.
- Barbituric_acid sameAs Ácido_barbitúrico.
- Barbituric_acid sameAs Acide_barbiturique.
- Barbituric_acid sameAs Acido_barbiturico.
- Barbituric_acid sameAs バルビツール酸.
- Barbituric_acid sameAs Barbituurzuur.
- Barbituric_acid sameAs Kwas_barbiturowy.
- Barbituric_acid sameAs Ácido_barbitúrico.
- Barbituric_acid sameAs m.05mffq.
- Barbituric_acid sameAs Q410278.
- Barbituric_acid sameAs Q410278.
- Barbituric_acid wasDerivedFrom Barbituric_acid?oldid=606427393.
- Barbituric_acid depiction Barbituric_acid.png.
- Barbituric_acid isPrimaryTopicOf Barbituric_acid.
