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- Bence_Jones_protein abstract "A Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22-24 kDa. Detection of Bence Jones protein may be suggestive of multiple myeloma or Waldenström's macroglobulinemia.Bence Jones proteins are particularly diagnostic of multiple myeloma in the context of end-organ manifestations such as renal failure, lytic (or "punched out") bone lesions, anemia, or large numbers of plasma cells in the bone marrow of patients. Bence Jones proteins are present in 2/3 of multiple myeloma cases.The proteins are immunoglobulin light chains (paraproteins) and are produced by neoplastic plasma cells. They can be kappa (most of the time) or lambda. The light chains can be immunoglobulin fragments or single homogeneous immunoglobulins. They are found in urine due to the kidneys' decreased filtration capabilities due to renal failure, sometimes induced by hypercalcemia from the calcium released as the bones are destroyed or from the light chains themselves.[citation needed] The light chains have historically been detected by heating and now by electrophoresis of concentrated urine. More recently serum free light chain assays have been utilised in a number of published studies which have indicated superiority over the urine tests, particularly for patients producing low levels of monoclonal free light chains, as seen in nonsecretory multiple myeloma and AL amyloidosis. This is primarily because of the re-absorption of free light chains in the kidneys, creating a "threshold" of light chain production which must be exceeded before measurable quantities overflow into the urine. As such, urinalysis is a fickle witness to changing free light chain production.".
- Bence_Jones_protein thumbnail Bence_Jones_Protein_MLE1.jpg?width=300.
- Bence_Jones_protein wikiPageID "2194578".
- Bence_Jones_protein wikiPageRevisionID "606011644".
- Bence_Jones_protein hasPhotoCollection Bence_Jones_protein.
- Bence_Jones_protein subject Category:Blood_tests.
- Bence_Jones_protein subject Category:Hematology.
- Bence_Jones_protein subject Category:Urine_tests.
- Bence_Jones_protein type Abstraction100002137.
- Bence_Jones_protein type Act100030358.
- Bence_Jones_protein type Activity100407535.
- Bence_Jones_protein type Assay100791527.
- Bence_Jones_protein type Attempt100786195.
- Bence_Jones_protein type Biopsy105740929.
- Bence_Jones_protein type BloodTest105742551.
- Bence_Jones_protein type BloodTests.
- Bence_Jones_protein type Cognition100023271.
- Bence_Jones_protein type DiagnosticTest105739043.
- Bence_Jones_protein type Event100029378.
- Bence_Jones_protein type Experiment105798043.
- Bence_Jones_protein type HigherCognitiveProcess105770664.
- Bence_Jones_protein type Inquiry105797597.
- Bence_Jones_protein type ProblemSolving105796750.
- Bence_Jones_protein type Process105701363.
- Bence_Jones_protein type PsychologicalFeature100023100.
- Bence_Jones_protein type Test100791078.
- Bence_Jones_protein type Thinking105770926.
- Bence_Jones_protein type Trial105799212.
- Bence_Jones_protein type UrineTests.
- Bence_Jones_protein type YagoPermanentlyLocatedEntity.
- Bence_Jones_protein comment "A Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22-24 kDa. Detection of Bence Jones protein may be suggestive of multiple myeloma or Waldenström's macroglobulinemia.Bence Jones proteins are particularly diagnostic of multiple myeloma in the context of end-organ manifestations such as renal failure, lytic (or "punched out") bone lesions, anemia, or large numbers of plasma cells in the bone marrow of patients.".
- Bence_Jones_protein label "Bence Jones protein".
- Bence_Jones_protein label "Bence-Jones-Protein".
- Bence_Jones_protein label "Białko Bence'a-Jonesa".
- Bence_Jones_protein label "Proteina di Bence Jones".
- Bence_Jones_protein label "Proteína de Bence Jones".
- Bence_Jones_protein label "Protéine de Bence-Jones".
- Bence_Jones_protein sameAs Bence-Jones-Protein.
- Bence_Jones_protein sameAs Proteína_de_Bence_Jones.
- Bence_Jones_protein sameAs Protéine_de_Bence-Jones.
- Bence_Jones_protein sameAs Proteina_di_Bence_Jones.
- Bence_Jones_protein sameAs Białko_Bence'a-Jonesa.
- Bence_Jones_protein sameAs m.06v05w.
- Bence_Jones_protein sameAs Q424176.
- Bence_Jones_protein sameAs Q424176.
- Bence_Jones_protein sameAs Bence_Jones_protein.
- Bence_Jones_protein wasDerivedFrom Bence_Jones_protein?oldid=606011644.
- Bence_Jones_protein depiction Bence_Jones_Protein_MLE1.jpg.
- Bence_Jones_protein isPrimaryTopicOf Bence_Jones_protein.
