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- Beta_oxidation abstract "Beta-oxidation is the process by which fatty acid molecules are broken down in the mitochondria to generate acetyl-coA, which enters the citric acid cycle, and NADH and FADH2, which are used by the electron transport chain.Fatty Acid Catabolism involve three stages. The first stage of fatty acid catabolism is Beta-Oxidation.The second stage is acetyl CoA oxidation to carbon dioxide.The third stage is electron transfer from electron carriers to the electron transfer chain. Priming the fatty acid for oxidation: Carnitine Shuttle Acyl CoA is transferred to the hydroxyl group of carnitine by carnitine palmitoyltransferase I (palmitoyltransferase) located on the outer mitochondrial membrane Acylcarnitine is shuttled inside by a carnitine-acylcarnitine translocase Acylcarnitine is converted back to acyl CoA by carnitine acyltransferase II (palmitoyltransferase) located on the inner mitochondrial membrane. The liberated carnitine returns to the cytosol.Once the fatty acid is inside the mitochondrial matrix, Beta Oxidation can begin. It has 4 steps. Step 1 of Beta-Oxidation: Long chain fatty acid is dehydrogenated to create a trans double bond between C2 and C3. This is catalyzed by the fatty acyl CoA dehydrogenase to produce trans-delta 2-enoyl CoA. It uses FAD as an electron acceptor and it is reduced to FADH2. Step 2 of Beta-Oxidation: Trans-delta2-enoyl CoA is hydrated at the double bond to produce L-B-hydroxyacyl CoA. This is catalyzed by enoyl CoA hydratase. Step 3 of Beta- Oxidation: L-B-hydroxyacyl CoA is dehydrogenated again to create B-ketoacyl CoA by B-hydroxyacyl CoA dehydrogenase. This enzyme uses NAD as an electron acceptor. Step 4 of Beta-Oxidation: Thiolysis occurs between C2 and C3 (alpha and beta carbons) of B-ketoacyl CoA. Thiolase enzyme catalyzes the reaction when a new molecule of coenzyme A breaks the bond by nucleophilic attack on C3. This releases the first two carbon units, as acetyl CoA, and a fatty acyl CoA minus two carbons. The process continues until all of the carbons in the fatty acid are turned into acetyl CoA. Fatty acids are oxidized by most of the tissues in the body. However, some tissues such as the adrenal medulla do not use fatty acids for their energy requirements and instead use carbohydrates.".
- Beta_oxidation thumbnail LCHAD_deficiency.jpg?width=300.
- Beta_oxidation wikiPageExternalLink carnitine1.html.
- Beta_oxidation wikiPageExternalLink 3060.
- Beta_oxidation wikiPageExternalLink fatty.htm.
- Beta_oxidation wikiPageID "2073471".
- Beta_oxidation wikiPageRevisionID "602767899".
- Beta_oxidation hasPhotoCollection Beta_oxidation.
- Beta_oxidation subject Category:Cell_biology.
- Beta_oxidation subject Category:Cellular_respiration.
- Beta_oxidation subject Category:Citric_acid_cycle.
- Beta_oxidation subject Category:Fatty_acids.
- Beta_oxidation subject Category:Metabolic_pathways.
- Beta_oxidation type Abstraction100002137.
- Beta_oxidation type Acid114607521.
- Beta_oxidation type CarboxylicAcid114739360.
- Beta_oxidation type Chemical114806838.
- Beta_oxidation type Compound114818238.
- Beta_oxidation type FattyAcid114740227.
- Beta_oxidation type FattyAcids.
- Beta_oxidation type Material114580897.
- Beta_oxidation type Matter100020827.
- Beta_oxidation type Part113809207.
- Beta_oxidation type PhysicalEntity100001930.
- Beta_oxidation type Relation100031921.
- Beta_oxidation type Substance100019613.
- Beta_oxidation comment "Beta-oxidation is the process by which fatty acid molecules are broken down in the mitochondria to generate acetyl-coA, which enters the citric acid cycle, and NADH and FADH2, which are used by the electron transport chain.Fatty Acid Catabolism involve three stages. The first stage of fatty acid catabolism is Beta-Oxidation.The second stage is acetyl CoA oxidation to carbon dioxide.The third stage is electron transfer from electron carriers to the electron transfer chain.".
- Beta_oxidation label "Beta ossidazione".
- Beta_oxidation label "Beta oxidación".
- Beta_oxidation label "Beta oxidation".
- Beta_oxidation label "Beta-oksydacja".
- Beta_oxidation label "Betaoxidação".
- Beta_oxidation label "Bèta-oxidatie".
- Beta_oxidation label "Bêta-oxydation".
- Beta_oxidation label "Β-Oxidation".
- Beta_oxidation label "Β-氧化".
- Beta_oxidation label "Β酸化".
- Beta_oxidation label "أكسدة الحمض الدهني".
- Beta_oxidation sameAs Beta-oxidace.
- Beta_oxidation sameAs Β-Oxidation.
- Beta_oxidation sameAs Beta_oxidación.
- Beta_oxidation sameAs Beta_oxidazio.
- Beta_oxidation sameAs Bêta-oxydation.
- Beta_oxidation sameAs Beta_ossidazione.
- Beta_oxidation sameAs Β酸化.
- Beta_oxidation sameAs Bèta-oxidatie.
- Beta_oxidation sameAs Beta-oksydacja.
- Beta_oxidation sameAs Betaoxidação.
- Beta_oxidation sameAs m.06k9c9.
- Beta_oxidation sameAs Q306213.
- Beta_oxidation sameAs Q306213.
- Beta_oxidation sameAs Beta_oxidation.
- Beta_oxidation wasDerivedFrom Beta_oxidation?oldid=602767899.
- Beta_oxidation depiction LCHAD_deficiency.jpg.
- Beta_oxidation isPrimaryTopicOf Beta_oxidation.
