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- Bicuculline abstract "Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. Since it blocks the inhibitory action of GABA receptors, the action of bicuculline mimics epilepsy. This property is utilized in laboratories across the world in the in vitro study of epilepsy, generally in hippocampal or cortical neurons in prepared brain slices from rodents. This compound is also routinely used to isolate glutamatergic (excitatory amino acid) receptor function.The action of bicuculline is primarily on the ionotropic GABAA receptors, which are ligand-gated ion channels concerned chiefly with the passing of chloride ions across the cell membrane, thus promoting an inhibitory influence on the target neuron. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.The half-maximal inhibitory concentration (IC50) of bicuculline on GABAA receptors is 3 μM.In addition to being a potent GABAA receptor antagonist, bicuculline can be used to block Ca2+-activated potassium channels.Sensitivity to bicuculline is defined by IUPHAR as a major criterion in the definition of GABAA receptors".
- Bicuculline atcPrefix "none".
- Bicuculline casNumber "485-49-4".
- Bicuculline chEBI "3092".
- Bicuculline fdaUniiCode "Y37615DVKC".
- Bicuculline iupacName "(6R)-​6-​[(5S)-​6-​methyl-​5,​6,​7,​8-​tetrahydro​[1,3]dioxolo​[4,5-g]​isoquinolin-​5-​yl]​furo[3,4-e]​[1,3]​benzodioxol-​8(6H)-​one".
- Bicuculline pubchem "10237".
- Bicuculline thumbnail Bicuculline.svg?width=300.
- Bicuculline wikiPageID "903124".
- Bicuculline wikiPageRevisionID "593216334".
- Bicuculline atcPrefix "none".
- Bicuculline c "20".
- Bicuculline casNumber "485".
- Bicuculline chebi "3092".
- Bicuculline chembl "417990".
- Bicuculline chemspiderid "9820".
- Bicuculline h "17".
- Bicuculline hasPhotoCollection Bicuculline.
- Bicuculline inchi "1".
- Bicuculline inchikey "IYGYMKDQCDOMRE-ZWKOTPCHBP".
- Bicuculline iupacName "-​6-​[-​6-​methyl-​5,​6,​7,​8-​tetrahydro​[1,3]dioxolo​[4,5-g]​isoquinolin-​5-​yl]​furo[3,4-e]​[1,3]​benzodioxol-​8-​one".
- Bicuculline iupharLigand "2312".
- Bicuculline molecularWeight "367.352".
- Bicuculline n "1".
- Bicuculline o "6".
- Bicuculline pubchem "10237".
- Bicuculline smiles "O=C1O[C@H][C@@H]5c4cc6OCOc6cc4CCN5C".
- Bicuculline stdinchi "1".
- Bicuculline stdinchikey "IYGYMKDQCDOMRE-ZWKOTPCHSA-N".
- Bicuculline unii "Y37615DVKC".
- Bicuculline verifiedfields "changed".
- Bicuculline verifiedrevid "401928349".
- Bicuculline width "200".
- Bicuculline subject Category:Convulsants.
- Bicuculline subject Category:Dioxoloisoquinolines.
- Bicuculline subject Category:GABA_antagonists.
- Bicuculline subject Category:Isobenzofurans.
- Bicuculline subject Category:Lactones.
- Bicuculline type Adversary109773245.
- Bicuculline type CausalAgent100007347.
- Bicuculline type GABAAntagonists.
- Bicuculline type LivingThing100004258.
- Bicuculline type Object100002684.
- Bicuculline type Organism100004475.
- Bicuculline type Person100007846.
- Bicuculline type PhysicalEntity100001930.
- Bicuculline type Whole100003553.
- Bicuculline type YagoLegalActor.
- Bicuculline type YagoLegalActorGeo.
- Bicuculline type Drug.
- Bicuculline type DrugProduct.
- Bicuculline type FunctionalSubstance.
- Bicuculline comment "Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. Since it blocks the inhibitory action of GABA receptors, the action of bicuculline mimics epilepsy.".
- Bicuculline label "Bicucullina".
- Bicuculline label "Bicuculline".
- Bicuculline sameAs Bicucullina.
- Bicuculline sameAs m.03ndxz.
- Bicuculline sameAs Q3639734.
- Bicuculline sameAs Q3639734.
- Bicuculline sameAs Bicuculline.
- Bicuculline wasDerivedFrom Bicuculline?oldid=593216334.
- Bicuculline depiction Bicuculline.svg.
- Bicuculline isPrimaryTopicOf Bicuculline.
