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Blonanserin abstract "Blonanserin (Lonasen) is a relatively new atypical antipsychotic (approved by PMDA in January 2008) commercialized by Dainippon Sumitomo Pharma in Japan and Korea for the treatment of schizophrenia. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal symptoms, excessive sedation, or hypotension. As with many second-generation (atypical) antipsychotics it is significantly more efficacious in the treatment of the negative symptoms of schizophrenia compared to first-generation (typical) antipsychotics such as haloperidol.Blonanserin acts as a mixed 5-HT2A (Ki = 0.812 nM) and D2 receptor (Ki = 0.142 nM) antagonist and also exerts some blockade of α1-adrenergic receptors (Ki = 26.7 nM). It lacks significant affinity for numerous other sites including the 5-HT1A, 5-HT3, D1, α2-adrenergic, β-adrenergic, H1, and mACh receptors and the monoamine transporters, though it does possess low affinity for the sigma receptor (IC50 = 286 nM).It has a relatively high affinity towards the 5-HT6 receptor perhaps underpinning its recently unveiled efficacy in treating the cognitive symptoms of schizophrenia.* Towards human receptors unless otherwise specified.".
Blonanserin atcPrefix "none".
Blonanserin bioavailability "55.0".
Blonanserin casNumber "132810-10-7".
Blonanserin fdaUniiCode "AQ316B4F8C".
Blonanserin iupacName "2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine".
Blonanserin pubchem "125564".
Blonanserin thumbnail Blonanserin2D.svg?width=300.
Blonanserin wikiPageID "18617373".
Blonanserin wikiPageRevisionID "590798974".
Blonanserin atcPrefix "none".
Blonanserin bioavailability "55.0".
Blonanserin c "23".
Blonanserin casNumber "132810".
Blonanserin chemspiderid "111697".
Blonanserin eliminationHalfLife "43200.0".
Blonanserin excretion "59".
Blonanserin f "1".
Blonanserin h "30".
Blonanserin hasPhotoCollection Blonanserin.
Blonanserin image "Blonanserin3Dan2.gif".
Blonanserin inchi "1".
Blonanserin inchikey "XVGOZDAJGBALKS-UHFFFAOYAW".
Blonanserin iupacName "2".
Blonanserin kegg "D01176".
Blonanserin legalStatus "Rx-only".
Blonanserin metabolism CYP3A4.
Blonanserin molecularWeight "367.5".
Blonanserin n "3".
Blonanserin pubchem "125564".
Blonanserin routesOfAdministration "Oral".
Blonanserin smiles "Fc1cccc2ccN4CCNCC4".
Blonanserin tradename "Lonasen".
Blonanserin unii "AQ316B4F8C".
Blonanserin width "200".
Blonanserin subject Category:5-HT2_antagonists.
Blonanserin subject Category:Atypical_antipsychotics.
Blonanserin subject Category:D2_antagonists.
Blonanserin subject Category:Organofluorides.
Blonanserin subject Category:Piperazines.
Blonanserin type 5-HT2Antagonists.
Blonanserin type Adversary109773245.
Blonanserin type CausalAgent100007347.
Blonanserin type D2Antagonists.
Blonanserin type LivingThing100004258.
Blonanserin type Object100002684.
Blonanserin type Organism100004475.
Blonanserin type Person100007846.
Blonanserin type PhysicalEntity100001930.
Blonanserin type Whole100003553.
Blonanserin type YagoLegalActor.
Blonanserin type YagoLegalActorGeo.
Blonanserin type Drug.
Blonanserin type DrugProduct.
Blonanserin type FunctionalSubstance.
Blonanserin comment "Blonanserin (Lonasen) is a relatively new atypical antipsychotic (approved by PMDA in January 2008) commercialized by Dainippon Sumitomo Pharma in Japan and Korea for the treatment of schizophrenia. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal symptoms, excessive sedation, or hypotension.".
Blonanserin label "Blonanserin".
Blonanserin label "ブロナンセリン".
Blonanserin sameAs ブロナンセリン.
Blonanserin sameAs m.04grr4d.
Blonanserin sameAs Q4927426.
Blonanserin sameAs Q4927426.
Blonanserin sameAs Blonanserin.
Blonanserin wasDerivedFrom Blonanserin?oldid=590798974.
Blonanserin depiction Blonanserin2D.svg.
Blonanserin isPrimaryTopicOf Blonanserin.