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- Bottromycin abstract "Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, an aminoglycoside antibiotic, and methicillin, a beta-lactam antibiotic.Bottromycin binds to the A site of the ribosome and blocks the binding of aminoacyl-tRNA, therefore inhibiting bacterial protein synthesis. Although bottromycin exhibits antibacterial activity in vitro, it has not yet been developed as a clinical antibiotic, potentially due to its poor stability in blood plasma. To increase its stability in vivo, some bottromycin derivatives have been explored.The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring. The absolute stereochemistry at several chiral centers has been determined as of 2009. In 2012, a three-dimensional solution structure of bottromycin was published. The solution structure revealed that several methyl groups are on the same face of the structure.".
- Bottromycin thumbnail Chemical_structure_of_bottromycin_A2.png?width=300.
- Bottromycin wikiPageID "41183836".
- Bottromycin wikiPageRevisionID "603737490".
- Bottromycin imagefile "Chemical structure of bottromycin A2.png".
- Bottromycin imagesize "300".
- Bottromycin othernames "Bottromycin A; Bottromycic A2 acid, methyl ester".
- Bottromycin subject Category:Antibiotics.
- Bottromycin subject Category:Nitrogen_compounds.
- Bottromycin subject Category:Organic_compounds.
- Bottromycin subject Category:Oxygen_compounds.
- Bottromycin subject Category:Peptides.
- Bottromycin subject Category:Streptomyces.
- Bottromycin subject Category:Thiazoles.
- Bottromycin type ChemicalCompound.
- Bottromycin type ChemicalSubstance.
- Bottromycin type ChemicalObject.
- Bottromycin type Thing.
- Bottromycin comment "Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma.".
- Bottromycin label "Bottromycin".
- Bottromycin sameAs m.0zdqlpt.
- Bottromycin sameAs Q15634144.
- Bottromycin sameAs Q15634144.
- Bottromycin wasDerivedFrom Bottromycin?oldid=603737490.
- Bottromycin depiction Chemical_structure_of_bottromycin_A2.png.
- Bottromycin isPrimaryTopicOf Bottromycin.
