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DBpedia 2014

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Bupropion abstract "Bupropion (/bjuːˈproʊpi.ɒn/ bew-PROH-pee-on;) is a drug primarily used as an atypical antidepressant and smoking cessation aid. Marketed as Wellbutrin, Budeprion, Prexaton, Elontril, Aplenzin, or other trade names, it is one of the most frequently prescribed antidepressants in the United States. Marketed in lower-dose formulations as Zyban, Voxra, or other names, it is also widely used to reduce nicotine cravings by people who are trying to quit smoking. It is taken in the form of pills, and in the United States is available only by prescription.Medically, bupropion serves as a non-tricyclic antidepressant fundamentally different from most commonly prescribed antidepressants such as selective serotonin reuptake inhibitors (SSRIs). It is an effective antidepressant on its own, but is also popular as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. In contrast to many other antidepressants, it does not cause weight gain or sexual dysfunction. The most important side effect is an increase in risk for epileptic seizures, which caused the drug to be withdrawn from the market for some time and then caused the recommended dosage to be reduced. 300 mg a day (for average body weight) has been shown not to increase risk of unprovoked seizure.Bupropion affects a number of neurotransmitter systems, and its mechanisms of action are only partly understood. A norepinephrine-dopamine reuptake inhibitor, the primary pharmacological action of the drug is as a mild dopamine reuptake inhibitor and also a much weaker norepinephrine reuptake inhibitor as well as a nicotinic acetylcholine receptor antagonist. Chemically, bupropion belongs to the class of aminoketones and is similar in structure to stimulants such as cathinone and amfepramone, and to phenethylamines in general.Bupropion was patented in 1969 by Burroughs Wellcome, which later became part of what is now GlaxoSmithKline. It was originally called amfebutamone, before being renamed in 2000. Its chemical name is 3-chloro-N-tert-butyl-β-ketoamphetamine. It is a substituted cathinone (β-ketoamphetamine), as well as a substituted amphetamine.".
Bupropion atcPrefix "N06".
Bupropion atcSuffix "AX12".
Bupropion casNumber "34841-39-9".
Bupropion chEBI "3219".
Bupropion drugbank "DB01156".
Bupropion fdaUniiCode "01ZG3TPX31".
Bupropion iupacName "(±)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one".
Bupropion pubchem "444".
Bupropion thumbnail Bupropion_skeletal.svg?width=300.
Bupropion wikiPageExternalLink ucm322161.htm.
Bupropion wikiPageExternalLink p30-b04.html.
Bupropion wikiPageExternalLink bupropion.html.
Bupropion wikiPageExternalLink ContentDisplay.cfm&ContentID=7388.
Bupropion wikiPageExternalLink buprop_cp.htm.
Bupropion wikiPageExternalLink www.wellbutrin-xl.com.
Bupropion wikiPageID "378579".
Bupropion wikiPageRevisionID "606296575".
Bupropion atcPrefix "N06".
Bupropion atcSuffix "AX12".
Bupropion c "13".
Bupropion casNumber "34841".
Bupropion chebi "3219".
Bupropion chembl "894".
Bupropion chemspiderid "431".
Bupropion cl "1".
Bupropion dependencyLiability "low".
Bupropion drugName "Bupropion".
Bupropion drugbank "DB01156".
Bupropion eliminationHalfLife "133200.0".
Bupropion excretion Feces.
Bupropion excretion Kidney.
Bupropion h "18".
Bupropion hasPhotoCollection Bupropion.
Bupropion image "Bupropion3Dan3.gif".
Bupropion imagename "1".
Bupropion inchi "1".
Bupropion iupacName "-2".
Bupropion kegg "D07591".
Bupropion legalAu "S4".
Bupropion legalCa "Rx-only".
Bupropion legalUk "POM".
Bupropion legalUs "Rx-only".
Bupropion licenceUs "Bupropion".
Bupropion medlineplus "a695033".
Bupropion metabolism "Hepatic".
Bupropion molecularWeight "239.74".
Bupropion n "1".
Bupropion o "1".
Bupropion pregnancyAu "B2".
Bupropion pregnancyUs "C".
Bupropion proteinBound "84".
Bupropion pubchem "444".
Bupropion routesOfAdministration "Oral".
Bupropion smiles "O=CC1=CC=CC=C1".
Bupropion stdinchi "1".
Bupropion stdinchikey "SNPPWIUOZRMYNY-UHFFFAOYSA-N".
Bupropion tradename "Wellbutrin, Zyban".
Bupropion unii "1".
Bupropion verifiedfields "changed".
Bupropion verifiedrevid "443491992".
Bupropion watchedfields "changed".
Bupropion width "180".
Bupropion width "200".
Bupropion subject Category:Cathinones.
Bupropion subject Category:Nicotinic_antagonists.
Bupropion subject Category:Norepinephrine-dopamine_reuptake_inhibitors.
Bupropion subject Category:Organochlorides.
Bupropion subject Category:Smoking_cessation.
Bupropion subject Category:Stimulants.
Bupropion type Agent114778436.
Bupropion type Antidepressant102718811.
Bupropion type Antidepressants.
Bupropion type CausalAgent100007347.
Bupropion type Drug103247620.
Bupropion type Inhibitor114724436.
Bupropion type Matter100020827.
Bupropion type Medicine103740161.
Bupropion type Norepinephrine-dopamineReuptakeInhibitors.
Bupropion type PhysicalEntity100001930.
Bupropion type Substance100020090.
Bupropion type Drug.
Bupropion type DrugProduct.
Bupropion type FunctionalSubstance.
Bupropion comment "Bupropion (/bjuːˈproʊpi.ɒn/ bew-PROH-pee-on;) is a drug primarily used as an atypical antidepressant and smoking cessation aid. Marketed as Wellbutrin, Budeprion, Prexaton, Elontril, Aplenzin, or other trade names, it is one of the most frequently prescribed antidepressants in the United States. Marketed in lower-dose formulations as Zyban, Voxra, or other names, it is also widely used to reduce nicotine cravings by people who are trying to quit smoking.".
Bupropion label "Bupropion".
Bupropion label "Bupropion".
Bupropion label "Bupropion".
Bupropion label "Bupropion".
Bupropion label "Bupropion".
Bupropion label "Bupropion".
Bupropion label "Bupropiona".
Bupropion label "Bupropione".
Bupropion label "Бупропион".
Bupropion label "بوبروبيون".
Bupropion label "ブプロピオン".
Bupropion label "丁氨苯丙酮".
Bupropion sameAs Bupropion.
Bupropion sameAs Βουπροπιόνη.
Bupropion sameAs Bupropion.