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- C-Met abstract "c-Met (MET or MNNG HOS Transforming gene) is a proto-oncogene that encodes a protein known as hepatocyte growth factor receptor (HGFR). The hepatocyte growth factor receptor protein possesses tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.MET is a membrane receptor that is essential for embryonic development and wound healing. Hepatocyte growth factor (HGF) is the only known ligand of the MET receptor. MET is normally expressed by cells of epithelial origin, while expression of HGF is restricted to cells of mesenchymal origin. Upon HGF stimulation, MET induces several biological responses that collectively give rise to a program known as invasive growth.Abnormal MET activation in cancer correlates with poor prognosis, where aberrantly active MET triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body.Various mutations in the MET gene are associated with papillary renal carcinoma.".
- C-Met entrezgene "4233".
- C-Met thumbnail Met_Structure.jpg?width=300.
- C-Met wikiPageExternalLink P08581.
- C-Met wikiPageExternalLink entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4233&ordinalpos=1&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum.
- C-Met wikiPageExternalLink met.
- C-Met wikiPageExternalLink Home.
- C-Met wikiPageID "2824931".
- C-Met wikiPageRevisionID "606347242".
- C-Met hasPhotoCollection C-Met.
- C-Met subject Category:EC_2.7.1.
- C-Met subject Category:Tyrosine_kinases.
- C-Met type Biomolecule.
- C-Met type Protein.
- C-Met type BiologicalObject.
- C-Met comment "c-Met (MET or MNNG HOS Transforming gene) is a proto-oncogene that encodes a protein known as hepatocyte growth factor receptor (HGFR). The hepatocyte growth factor receptor protein possesses tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.MET is a membrane receptor that is essential for embryonic development and wound healing.".
- C-Met label "C-MET".
- C-Met label "C-Met".
- C-Met sameAs C-MET.
- C-Met sameAs m.0852c8.
- C-Met sameAs Q5005897.
- C-Met sameAs Q5005897.
- C-Met sameAs 1144.
- C-Met sameAs 1864.
- C-Met wasDerivedFrom C-Met?oldid=606347242.
- C-Met depiction Met_Structure.jpg.
- C-Met isPrimaryTopicOf C-Met.
