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- C-fos-induced_growth_factor abstract "C-fos-induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene.The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor C.Tumor metastasis to lymph nodes:Lymph node metastasis is very often associated with several types of human malignancies. Cancer cells’ journey to lymph node takes place largely through lymphatic tunnel located in and around of primary tumor. VEGF-D’s interactions with VEGFR-3 predominantly expressed in lymphatic vessels plays a key role in restructuring lymphatic channel and, hence, able to alter its functions related to fluid and cell transport along the conduits. VEGF-D has been established to be over-expressed in both tumor tissues and patients’ serum samples in several types of human cancer. In addition, VEGF-D expression has been implicated with increased incidence of regional lymph node metastasis. In experimental mice study, genetically modified tumor cell that was forced to produce VEGF-D protein have been established to boost up regional lymph nodes metastases.".
- C-fos-induced_growth_factor entrezgene "2277".
- C-fos-induced_growth_factor wikiPageID "14760983".
- C-fos-induced_growth_factor wikiPageRevisionID "594258961".
- C-fos-induced_growth_factor requireManualInspection "no".
- C-fos-induced_growth_factor summaryText "The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor C.".
- C-fos-induced_growth_factor updateCitations "yes".
- C-fos-induced_growth_factor updatePage "yes".
- C-fos-induced_growth_factor updateProteinBox "yes".
- C-fos-induced_growth_factor updateSummary "yes".
- C-fos-induced_growth_factor type Biomolecule.
- C-fos-induced_growth_factor type Protein.
- C-fos-induced_growth_factor type BiologicalObject.
- C-fos-induced_growth_factor comment "C-fos-induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene.The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth.".
- C-fos-induced_growth_factor label "C-fos-induced growth factor".
- C-fos-induced_growth_factor sameAs m.03gx16m.
- C-fos-induced_growth_factor sameAs Q5005938.
- C-fos-induced_growth_factor sameAs Q5005938.
- C-fos-induced_growth_factor wasDerivedFrom C-fos-induced_growth_factor?oldid=594258961.
- C-fos-induced_growth_factor isPrimaryTopicOf C-fos-induced_growth_factor.