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- CBFB abstract "Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene.The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. Mutations in CBFB are implicated in cases of breast cancer.".
- CBFB entrezgene "865".
- CBFB wikiPageID "14181500".
- CBFB wikiPageRevisionID "597685217".
- CBFB hasPhotoCollection CBFB.
- CBFB requireManualInspection "no".
- CBFB summaryText "The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis and osteogenesis . The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.".
- CBFB updateCitations "yes".
- CBFB updatePage "yes".
- CBFB updateProteinBox "yes".
- CBFB updateSummary "yes".
- CBFB type Biomolecule.
- CBFB type Protein.
- CBFB type BiologicalObject.
- CBFB comment "Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene.The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2).".
- CBFB label "CBFB".
- CBFB sameAs m.03cx2z7.
- CBFB sameAs Q5009085.
- CBFB sameAs Q5009085.
- CBFB sameAs CBFB.
- CBFB wasDerivedFrom CBFB?oldid=597685217.
- CBFB isPrimaryTopicOf CBFB.