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- CHRFAM7A abstract "CHRNA7-FAM7A fusion protein is a protein that in humans is encoded by the CHRFAM7A gene.The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.".
- CHRFAM7A entrezgene "89832".
- CHRFAM7A wikiPageID "15181525".
- CHRFAM7A wikiPageRevisionID "593740857".
- CHRFAM7A hasPhotoCollection CHRFAM7A.
- CHRFAM7A requireManualInspection "no".
- CHRFAM7A summaryText "The nicotinic acetylcholine receptors are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 . Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.".
- CHRFAM7A updateCitations "yes".
- CHRFAM7A updatePage "yes".
- CHRFAM7A updateProteinBox "yes".
- CHRFAM7A updateSummary "yes".
- CHRFAM7A type Biomolecule.
- CHRFAM7A type Protein.
- CHRFAM7A type BiologicalObject.
- CHRFAM7A comment "CHRNA7-FAM7A fusion protein is a protein that in humans is encoded by the CHRFAM7A gene.The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A).".
- CHRFAM7A label "CHRFAM7A".
- CHRFAM7A sameAs m.03hl1rv.
- CHRFAM7A sameAs Q5011305.
- CHRFAM7A sameAs Q5011305.
- CHRFAM7A wasDerivedFrom CHRFAM7A?oldid=593740857.
- CHRFAM7A isPrimaryTopicOf CHRFAM7A.