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- CHRNA7 abstract "Neuronal acetylcholine receptor subunit alpha-7 is a protein that in humans is encoded by the CHRNA7 gene.The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene.".
- CHRNA7 entrezgene "1139".
- CHRNA7 wikiPageExternalLink index.html?query=chrna7&fa=false&e_fa=t.
- CHRNA7 wikiPageID "14477915".
- CHRNA7 wikiPageRevisionID "593752080".
- CHRNA7 hasPhotoCollection CHRNA7.
- CHRNA7 requireManualInspection "no".
- CHRNA7 summaryText "The nicotinic acetylcholine receptors are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene.".
- CHRNA7 updateCitations "yes".
- CHRNA7 updatePage "yes".
- CHRNA7 updateProteinBox "yes".
- CHRNA7 updateSummary "yes".
- CHRNA7 subject Category:Ion_channels.
- CHRNA7 type Biomolecule.
- CHRNA7 type Protein.
- CHRNA7 type BiologicalObject.
- CHRNA7 comment "Neuronal acetylcholine receptor subunit alpha-7 is a protein that in humans is encoded by the CHRNA7 gene.The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits.".
- CHRNA7 label "CHRNA7".
- CHRNA7 sameAs m.03d4sys.
- CHRNA7 sameAs Q5011320.
- CHRNA7 sameAs Q5011320.
- CHRNA7 sameAs 4095.
- CHRNA7 wasDerivedFrom CHRNA7?oldid=593752080.
- CHRNA7 isPrimaryTopicOf CHRNA7.