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- CISH abstract "Cytokine-inducible SH2-containing protein is a protein that in humans is encoded by the CISH gene. CISH orthologs have been identified in most mammals with sequenced genomes. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria.The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor.".
- CISH entrezgene "1154".
- CISH wikiPageID "14772933".
- CISH wikiPageRevisionID "593772041".
- CISH hasPhotoCollection CISH.
- CISH requireManualInspection "no".
- CISH summaryText "The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor , also known as suppressor of cytokine signaling or STAT-induced STAT inhibitor , protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor.".
- CISH updateCitations "yes".
- CISH updatePage "yes".
- CISH updateProteinBox "yes".
- CISH updateSummary "yes".
- CISH subject Category:Genes_mutated_in_mice.
- CISH type Abstraction100002137.
- CISH type Arrangement107938773.
- CISH type Gene105436752.
- CISH type GenesMutatedInMice.
- CISH type Group100031264.
- CISH type Ordering108456993.
- CISH type Sequence108459252.
- CISH type Series108457976.
- CISH type Biomolecule.
- CISH type Protein.
- CISH type BiologicalObject.
- CISH comment "Cytokine-inducible SH2-containing protein is a protein that in humans is encoded by the CISH gene. CISH orthologs have been identified in most mammals with sequenced genomes. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria.The protein encoded by this gene contains a SH2 domain and a SOCS box domain.".
- CISH label "CISH".
- CISH sameAs m.03gxhzt.
- CISH sameAs Q5011866.
- CISH sameAs Q5011866.
- CISH sameAs CISH.
- CISH wasDerivedFrom CISH?oldid=593772041.
- CISH isPrimaryTopicOf CISH.