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- COX10 abstract "Protoheme IX farnesyltransferase, mitochondrial is an enzyme that in humans is encoded by the COX10 gene.Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.".
- COX10 entrezgene "1352".
- COX10 wikiPageID "15068317".
- COX10 wikiPageRevisionID "593866752".
- COX10 hasPhotoCollection COX10.
- COX10 requireManualInspection "no".
- COX10 summaryText "Cytochrome c oxidase , the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine , is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A duplication and with HNPP deletion.".
- COX10 updateCitations "yes".
- COX10 updatePage "yes".
- COX10 updateProteinBox "yes".
- COX10 updateSummary "yes".
- COX10 type Biomolecule.
- COX10 type Protein.
- COX10 type BiologicalObject.
- COX10 comment "Protoheme IX farnesyltransferase, mitochondrial is an enzyme that in humans is encoded by the COX10 gene.Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.".
- COX10 label "COX10".
- COX10 label "Protohäm-IX-Farnesyltransferase".
- COX10 sameAs Protohäm-IX-Farnesyltransferase.
- COX10 sameAs m.03hggbm.
- COX10 sameAs Q2113671.
- COX10 sameAs Q2113671.
- COX10 sameAs COX10.
- COX10 wasDerivedFrom COX10?oldid=593866752.
- COX10 isPrimaryTopicOf COX10.