Matches in DBpedia 2014 for { <http://dbpedia.org/resource/CPEB> ?p ?o. }
Showing items 1 to 30 of
30
with 100 items per page.
- CPEB abstract "CPEB, or cytoplasmic polyadenylation element binding protein, is a highly conserved RNA-binding protein that promotes the elongation of the polyadenine tail of messenger RNA. CPEB most commonly activates the target RNA for translation, but can also act as a repressor, dependent on its phosphorylation state. In animals, CPEB is expressed in several alternative splicing isoforms that are specific to particular tissues and functions, including the self-cleaving Mammalian CPEB3 ribozyme. CPEB was first identified in Xenopus oocytes and associated with meiosis; a role has also been identified in the spermatogenesis of Caenorhabditis elegans.CPEB is involved in closed-loop regulation of mRNAs that keeps them inactive. The closed-loop structure between the 3'UTR and 5'UTR inhibits translation. This has been observed in Xenopus laevis in which eIF4E bound to the 5' cap interacts with Maskin bound to CPEB on the 3' UTR creating translationally inactive transcripts. This translational inhibition is lifted once CPEB is phosphorylated, displacing the Masking binding site, allowing for the polymerization of the PolyA tail, which can recruit the translational machinery by means of PABP. However, it is important to note that this mechanism has been under great scrutiny.".
- CPEB wikiPageID "11969499".
- CPEB wikiPageRevisionID "593867616".
- CPEB hasPhotoCollection CPEB.
- CPEB subject Category:Memory.
- CPEB subject Category:RNA-binding_proteins.
- CPEB type Abstraction100002137.
- CPEB type Chemical114806838.
- CPEB type Compound114818238.
- CPEB type Macromolecule114944888.
- CPEB type Material114580897.
- CPEB type Matter100020827.
- CPEB type Molecule114682133.
- CPEB type OrganicCompound114727670.
- CPEB type Part113809207.
- CPEB type PhysicalEntity100001930.
- CPEB type Protein114728724.
- CPEB type RNA-bindingProteins.
- CPEB type Relation100031921.
- CPEB type Substance100019613.
- CPEB type Thing100002452.
- CPEB type Unit109465459.
- CPEB comment "CPEB, or cytoplasmic polyadenylation element binding protein, is a highly conserved RNA-binding protein that promotes the elongation of the polyadenine tail of messenger RNA. CPEB most commonly activates the target RNA for translation, but can also act as a repressor, dependent on its phosphorylation state. In animals, CPEB is expressed in several alternative splicing isoforms that are specific to particular tissues and functions, including the self-cleaving Mammalian CPEB3 ribozyme.".
- CPEB label "CPEB".
- CPEB sameAs m.02r_2zh.
- CPEB sameAs Q5013631.
- CPEB sameAs Q5013631.
- CPEB sameAs CPEB.
- CPEB wasDerivedFrom CPEB?oldid=593867616.
- CPEB isPrimaryTopicOf CPEB.