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- CYB5R3 abstract "NADH-cytochrome b5 reductase 3 is an enzyme that in humans is encoded by the CYB5R3 gene.Two forms of NADH-cytochrome b5 reductase are known, a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The former exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains. The soluble form has only the catalytic domain. This gene encodes both forms of the enzyme which arise from tissue-specific alternative transcripts that differ in the first exon. Mutations in this gene cause methemoglobinemias.".
- CYB5R3 entrezgene "1727".
- CYB5R3 wikiPageID "14146458".
- CYB5R3 wikiPageRevisionID "593925196".
- CYB5R3 hasPhotoCollection CYB5R3.
- CYB5R3 requireManualInspection "no".
- CYB5R3 summaryText "Two forms of NADH-cytochrome b5 reductase are known, a membrane-bound form in somatic cells and a soluble form in erythrocytes. The former exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains. The soluble form has only the catalytic domain. This gene encodes both forms of the enzyme which arise from tissue-specific alternative transcripts that differ in the first exon. Mutations in this gene cause methemoglobinemias.".
- CYB5R3 updateCitations "yes".
- CYB5R3 updatePage "yes".
- CYB5R3 updateProteinBox "yes".
- CYB5R3 updateSummary "yes".
- CYB5R3 type Biomolecule.
- CYB5R3 type Protein.
- CYB5R3 type BiologicalObject.
- CYB5R3 comment "NADH-cytochrome b5 reductase 3 is an enzyme that in humans is encoded by the CYB5R3 gene.Two forms of NADH-cytochrome b5 reductase are known, a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The former exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism.".
- CYB5R3 label "CYB5R3".
- CYB5R3 sameAs m.03cw0mr.
- CYB5R3 sameAs Q5014913.
- CYB5R3 sameAs Q5014913.
- CYB5R3 sameAs CYB5R3.
- CYB5R3 sameAs 178.
- CYB5R3 sameAs 4488.
- CYB5R3 sameAs 5082.
- CYB5R3 wasDerivedFrom CYB5R3?oldid=593925196.
- CYB5R3 isPrimaryTopicOf CYB5R3.