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- CYTH4 abstract "Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. CYTH4 exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The CYTH4 and CYTH1 gene structures are very similar.".
- CYTH4 entrezgene "27128".
- CYTH4 wikiPageID "16849197".
- CYTH4 wikiPageRevisionID "593935334".
- CYTH4 hasPhotoCollection CYTH4.
- CYTH4 requireManualInspection "no".
- CYTH4 summaryText "This gene encodes a member of the cytohesin family, formerly known as the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. CYTH4 exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The CYTH4 and CYTH1 gene structures are very similar.".
- CYTH4 updateCitations "yes".
- CYTH4 updatePage "yes".
- CYTH4 updateProteinBox "yes".
- CYTH4 updateSummary "yes".
- CYTH4 type Biomolecule.
- CYTH4 type Protein.
- CYTH4 type BiologicalObject.
- CYTH4 comment "Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain.".
- CYTH4 label "CYTH4".
- CYTH4 sameAs m.04088fc.
- CYTH4 sameAs Q5015007.
- CYTH4 sameAs Q5015007.
- CYTH4 wasDerivedFrom CYTH4?oldid=593935334.
- CYTH4 isPrimaryTopicOf CYTH4.