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- Calcium-binding_EGF_domain abstract "In molecular biology, the calcium-binding EGF domain is a conserved domain of about forty amino-acid residues found in epidermal growth factor (EGF). This domain is present in a large number of membrane-bound and extracellular, mostly animal, proteins. Many of these proteins require calcium for their biological function and a calcium-binding site has been found at the N-terminus of some EGF-like domains. Calcium-binding may be crucial for numerous protein-protein interactions.For human coagulation factor IX it has been shown that the calcium-ligands form a pentagonal bipyramid. The first, third and fourth conserved negatively charged or polar residues are side chain ligands. The latter is possibly hydroxylated. A conserved aromatic residue, as well as the second conserved negative residue, are thought to be involved in stabilising the calcium-binding site.As in non-calcium binding EGF-like domains, there are six conserved cysteines and the structure of both types is very similar as calcium-binding induces only strictly local structural changes.".
- Calcium-binding_EGF_domain symbol "EGF_CA".
- Calcium-binding_EGF_domain thumbnail PDB_1szb_EBI.jpg?width=300.
- Calcium-binding_EGF_domain wikiPageID "32679450".
- Calcium-binding_EGF_domain wikiPageRevisionID "590845171".
- Calcium-binding_EGF_domain caption "crystal structure of the human mbl-associated protein 19".
- Calcium-binding_EGF_domain hasPhotoCollection Calcium-binding_EGF_domain.
- Calcium-binding_EGF_domain interpro "IPR013091".
- Calcium-binding_EGF_domain name "Calcium-binding EGF domain".
- Calcium-binding_EGF_domain pfam "PF07645".
- Calcium-binding_EGF_domain pfamClan "CL0001".
- Calcium-binding_EGF_domain symbol "EGF_CA".
- Calcium-binding_EGF_domain subject Category:Protein_domains.
- Calcium-binding_EGF_domain type Abstraction100002137.
- Calcium-binding_EGF_domain type Attribute100024264.
- Calcium-binding_EGF_domain type Environment113934596.
- Calcium-binding_EGF_domain type ProteinDomains.
- Calcium-binding_EGF_domain type Situation113927383.
- Calcium-binding_EGF_domain type Sphere114514039.
- Calcium-binding_EGF_domain type State100024720.
- Calcium-binding_EGF_domain type Biomolecule.
- Calcium-binding_EGF_domain type Protein.
- Calcium-binding_EGF_domain type BiologicalObject.
- Calcium-binding_EGF_domain comment "In molecular biology, the calcium-binding EGF domain is a conserved domain of about forty amino-acid residues found in epidermal growth factor (EGF). This domain is present in a large number of membrane-bound and extracellular, mostly animal, proteins. Many of these proteins require calcium for their biological function and a calcium-binding site has been found at the N-terminus of some EGF-like domains.".
- Calcium-binding_EGF_domain label "Calcium-binding EGF domain".
- Calcium-binding_EGF_domain sameAs m.0h3s2t_.
- Calcium-binding_EGF_domain sameAs Q5018798.
- Calcium-binding_EGF_domain sameAs Q5018798.
- Calcium-binding_EGF_domain sameAs Calcium-binding_EGF_domain.
- Calcium-binding_EGF_domain wasDerivedFrom Calcium-binding_EGF_domain?oldid=590845171.
- Calcium-binding_EGF_domain depiction PDB_1szb_EBI.jpg.
- Calcium-binding_EGF_domain isPrimaryTopicOf Calcium-binding_EGF_domain.
