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- Camptothecin abstract "Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.".
- Camptothecin atcPrefix "none".
- Camptothecin casNumber "7689-03-4".
- Camptothecin chEBI "27656".
- Camptothecin drugbank "DB04690".
- Camptothecin fdaUniiCode "XT3Z54Z28A".
- Camptothecin iupacName "(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]".
- Camptothecin iupacName "quinoline-3,14-(4H,12H)-dione".
- Camptothecin pubchem "2538".
- Camptothecin thumbnail Camptothecin.svg?width=300.
- Camptothecin wikiPageID "14127651".
- Camptothecin wikiPageRevisionID "592207051".
- Camptothecin atcPrefix "none".
- Camptothecin c "20".
- Camptothecin casNumber "7689-03-04".
- Camptothecin chebi "27656".
- Camptothecin chembl "65".
- Camptothecin chemspiderid "22775".
- Camptothecin drugbank "DB04690".
- Camptothecin h "16".
- Camptothecin hasPhotoCollection Camptothecin.
- Camptothecin inchi "1".
- Camptothecin inchikey "VSJKWCGYPAHWDS-FQEVSTJZBY".
- Camptothecin iupacName "-4".
- Camptothecin iupacName "quinoline-3,14--dione".
- Camptothecin kegg "1897.0".
- Camptothecin molecularWeight "348.352".
- Camptothecin n "2".
- Camptothecin o "4".
- Camptothecin pubchem "2538".
- Camptothecin smiles "O=C\1N4\Cc3nc5ccccc5".
- Camptothecin stdinchi "1".
- Camptothecin stdinchikey "VSJKWCGYPAHWDS-FQEVSTJZSA-N".
- Camptothecin unii "XT3Z54Z28A".
- Camptothecin verifiedrevid "443672460".
- Camptothecin subject Category:Alcohols.
- Camptothecin subject Category:Alkaloids.
- Camptothecin subject Category:Lactams.
- Camptothecin subject Category:Lactones.
- Camptothecin subject Category:Pyranoindolizinoquinolines.
- Camptothecin subject Category:Topoisomerase_inhibitors.
- Camptothecin type Abstraction100002137.
- Camptothecin type Agent114778436.
- Camptothecin type Alcohol107884567.
- Camptothecin type Alcohols.
- Camptothecin type Alkaloid114712692.
- Camptothecin type Alkaloids.
- Camptothecin type Beverage107881800.
- Camptothecin type CausalAgent100007347.
- Camptothecin type Chemical114806838.
- Camptothecin type Compound114818238.
- Camptothecin type Drug103247620.
- Camptothecin type DrugOfAbuse103248958.
- Camptothecin type Fluid114939900.
- Camptothecin type Food100021265.
- Camptothecin type Liquid114940386.
- Camptothecin type Material114580897.
- Camptothecin type Matter100020827.
- Camptothecin type OrganicCompound114727670.
- Camptothecin type Part113809207.
- Camptothecin type PhysicalEntity100001930.
- Camptothecin type Relation100031921.
- Camptothecin type Substance100019613.
- Camptothecin type Substance100020090.
- Camptothecin type Drug.
- Camptothecin type DrugProduct.
- Camptothecin type FunctionalSubstance.
- Camptothecin comment "Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine.".
- Camptothecin label "Camptotecina".
- Camptothecin label "Camptothecin".
- Camptothecin label "Camptothecin".
- Camptothecin label "Camptothecine".
- Camptothecin label "Camptothécine".
- Camptothecin label "カンプトテシン".
- Camptothecin label "喜树碱".
- Camptothecin sameAs Camptothecin.
- Camptothecin sameAs Camptotecina.
- Camptothecin sameAs Camptothécine.
- Camptothecin sameAs カンプトテシン.
- Camptothecin sameAs Camptothecine.
- Camptothecin sameAs m.0czz92.
- Camptothecin sameAs Q419964.
- Camptothecin sameAs Q419964.
- Camptothecin sameAs DB04690.
- Camptothecin sameAs Camptothecin.
- Camptothecin wasDerivedFrom Camptothecin?oldid=592207051.
- Camptothecin depiction Camptothecin.svg.
- Camptothecin isPrimaryTopicOf Camptothecin.
