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- Carpaine abstract "Carpaine is one of the major alkaloid components of papaya leaves which has been studied for its cardiovascular effects. Circulatory effects of carpaine were studied in Wistar male rats weighing 314 +/- 13 g, under pentobarbital (30 mg/kg) anesthesia. Increasing dosages of carpaine from 0.5 mg/kg to 2.0 mg/kg resulted in progressive decrease in systolic, diastolic, and mean arterial blood pressure. Selective autonomic nervous blockade with atropine sulfate (1 mg/kg) or propranolol hydrochloride (8 mg/kg) did not alter the circulatory response to carpaine. Carpaine, 2 mg/kg, reduced cardiac output, stroke volume, stroke work, and cardiac power, but the calculated total peripheral resistance remained unchanged. It is concluded from these results that carpaine affects the myocardium directly. The effects of carpaine may be related to its macrocyclic dilactone structure, a possible cation chelating structure.".
- Carpaine iupacName "(1S,11R,13S,14S,24R,26S)-13,26-Dimethyl-2,15-dioxa-".
- Carpaine iupacName "12,25-diazatricyclo[22.2.2.211,14]triacontane-3,16-dione".
- Carpaine thumbnail Carpaine.png?width=300.
- Carpaine wikiPageID "7949613".
- Carpaine wikiPageRevisionID "575377052".
- Carpaine hasPhotoCollection Carpaine.
- Carpaine imagefile "Carpaine.png".
- Carpaine iupacname "-1326".
- Carpaine iupacname "1225".
- Carpaine name "Carpaine".
- Carpaine othernames "-Carpaine".
- Carpaine verifiedrevid "399708506".
- Carpaine subject Category:Alkaloids.
- Carpaine subject Category:Lactones.
- Carpaine subject Category:Macrocycles.
- Carpaine subject Category:Piperidines.
- Carpaine type Abstraction100002137.
- Carpaine type Alkaloid114712692.
- Carpaine type Alkaloids.
- Carpaine type Chemical114806838.
- Carpaine type Compound114818238.
- Carpaine type Material114580897.
- Carpaine type Matter100020827.
- Carpaine type OrganicCompound114727670.
- Carpaine type Part113809207.
- Carpaine type PhysicalEntity100001930.
- Carpaine type Relation100031921.
- Carpaine type Substance100019613.
- Carpaine type ChemicalCompound.
- Carpaine type ChemicalSubstance.
- Carpaine type ChemicalSubstanceType.
- Carpaine type ChemicalObject.
- Carpaine type Thing.
- Carpaine comment "Carpaine is one of the major alkaloid components of papaya leaves which has been studied for its cardiovascular effects. Circulatory effects of carpaine were studied in Wistar male rats weighing 314 +/- 13 g, under pentobarbital (30 mg/kg) anesthesia. Increasing dosages of carpaine from 0.5 mg/kg to 2.0 mg/kg resulted in progressive decrease in systolic, diastolic, and mean arterial blood pressure.".
- Carpaine label "Carpaine".
- Carpaine label "Carpaína".
- Carpaine sameAs Carpaína.
- Carpaine sameAs m.026l435.
- Carpaine sameAs Q3179543.
- Carpaine sameAs Q3179543.
- Carpaine sameAs Carpaine.
- Carpaine wasDerivedFrom Carpaine?oldid=575377052.
- Carpaine depiction Carpaine.png.
- Carpaine isPrimaryTopicOf Carpaine.
- Carpaine name "Carpaine".
