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- Catalytic_triad abstract "A catalytic triad usually refers to the three amino acid residues that function together at the centre of the active site of certain hydrolase and transferase enzymes (e.g. proteases, amidases, esterases, acylases, lipases and β-lactamases). A common method for generating a nucleophilic residue for covalent catalysis is by using an Acid-Base-Nucleophile triad. The residues form a charge-relay network to polarise and activate the nucleophile, which attacks the substrate, forming a covalent intermediate which is then hydrolysed to regenerate free enzyme. The nucleophile is most commonly serine or cysteine but occasionally threonine.Because enzymes fold into complex three-dimensional shapes, the residues of a catalytic triad can be far from each other along the amino-acid sequence (primary structure), however, they are brought close together in the final fold.As well as divergent evolution of function (and even the triad's nucleophile), catalytic triads show some of the best examples of convergent evolution. Chemical constraints on catalysis have led to the same catalytic solution independently evolving in at least 23 separate superfamilies. Their mechanism of action is consequently one of the best studied in all of biochemistry.".
- Catalytic_triad thumbnail Catalytic_triad_of_TEV_protease.png?width=300.
- Catalytic_triad wikiPageExternalLink Lysinibacillus_sphaericus_C3-41.
- Catalytic_triad wikiPageID "2533237".
- Catalytic_triad wikiPageRevisionID "595113691".
- Catalytic_triad hasPhotoCollection Catalytic_triad.
- Catalytic_triad subject Category:Catalysis.
- Catalytic_triad subject Category:Evolution.
- Catalytic_triad subject Category:Molecular_biology.
- Catalytic_triad type Abstraction100002137.
- Catalytic_triad type Amide114724264.
- Catalytic_triad type Chemical114806838.
- Catalytic_triad type Compound114818238.
- Catalytic_triad type Material114580897.
- Catalytic_triad type Matter100020827.
- Catalytic_triad type OrganicCompound114727670.
- Catalytic_triad type Part113809207.
- Catalytic_triad type Peptide114743046.
- Catalytic_triad type Peptides.
- Catalytic_triad type PhysicalEntity100001930.
- Catalytic_triad type Relation100031921.
- Catalytic_triad type Substance100019613.
- Catalytic_triad comment "A catalytic triad usually refers to the three amino acid residues that function together at the centre of the active site of certain hydrolase and transferase enzymes (e.g. proteases, amidases, esterases, acylases, lipases and β-lactamases). A common method for generating a nucleophilic residue for covalent catalysis is by using an Acid-Base-Nucleophile triad.".
- Catalytic_triad label "Catalytic triad".
- Catalytic_triad label "Katalytische Triade".
- Catalytic_triad label "触媒三残基".
- Catalytic_triad sameAs Katalytische_Triade.
- Catalytic_triad sameAs 触媒三残基.
- Catalytic_triad sameAs m.07lf3m.
- Catalytic_triad sameAs Q751908.
- Catalytic_triad sameAs Q751908.
- Catalytic_triad sameAs Catalytic_triad.
- Catalytic_triad wasDerivedFrom Catalytic_triad?oldid=595113691.
- Catalytic_triad depiction Catalytic_triad_of_TEV_protease.png.
- Catalytic_triad isPrimaryTopicOf Catalytic_triad.
