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- Cathepsin_D abstract "Cathepsin D is a protein that in humans is encoded by the CTSD gene.This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.It has been used as a breast cancer tumor marker.Cathepsin-D is an aspartic protease that depends critically on protonation of its active site Asp residue and gets activated at pH 5 in endosome of hepatocytes where it degrades insulin. Along with Asp-protonation, lower pH also leads to conformational switch in cathepsin-D : the N terminal segment of the protease moves out of the active site as pH drops.".
- Cathepsin_D entrezgene "1509".
- Cathepsin_D wikiPageExternalLink merops.cgi?id=A01.009.
- Cathepsin_D wikiPageExternalLink br.fcgi?book=gene&part=ncl.
- Cathepsin_D wikiPageID "14722632".
- Cathepsin_D wikiPageRevisionID "590868049".
- Cathepsin_D hasPhotoCollection Cathepsin_D.
- Cathepsin_D requireManualInspection "no".
- Cathepsin_D summaryText "This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.".
- Cathepsin_D updateCitations "yes".
- Cathepsin_D updatePage "yes".
- Cathepsin_D updateProteinBox "yes".
- Cathepsin_D updateSummary "yes".
- Cathepsin_D subject Category:Peptidase.
- Cathepsin_D type Biomolecule.
- Cathepsin_D type Protein.
- Cathepsin_D type BiologicalObject.
- Cathepsin_D comment "Cathepsin D is a protein that in humans is encoded by the CTSD gene.This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript.".
- Cathepsin_D label "Cathepsin D".
- Cathepsin_D sameAs m.03gvj98.
- Cathepsin_D sameAs Q5052481.
- Cathepsin_D sameAs Q5052481.
- Cathepsin_D sameAs 1243.
- Cathepsin_D wasDerivedFrom Cathepsin_D?oldid=590868049.
- Cathepsin_D isPrimaryTopicOf Cathepsin_D.